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Nfkbil1 nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor like 1 [ Mus musculus (house mouse) ]

Gene ID: 18038, updated on 2-Nov-2024

Summary

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Official Symbol
Nfkbil1provided by MGI
Official Full Name
nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor like 1provided by MGI
Primary source
MGI:MGI:1340031
See related
Ensembl:ENSMUSG00000042419 AllianceGenome:MGI:1340031
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
IKBL; Def-7; ikappaBL
Summary
Enables transcription regulator inhibitor activity. Involved in negative regulation of canonical NF-kappaB signal transduction. Is active in nucleus. Is expressed in embryo; eye; and heart. Human ortholog(s) of this gene implicated in rheumatoid arthritis. Orthologous to human NFKBIL1 (NFKB inhibitor like 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in adrenal adult (RPKM 23.4), ovary adult (RPKM 20.9) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Nfkbil1 in Genome Data Viewer
Location:
17 B1; 17 18.6 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (35439151..35455457, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (35220175..35236481, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:35337508-35337695 Neighboring gene tumor necrosis factor Neighboring gene microRNA 6974 Neighboring gene lymphotoxin A Neighboring gene STARR-positive B cell enhancer ABC_E11642 Neighboring gene STARR-positive B cell enhancer ABC_E5601 Neighboring gene STARR-positive B cell enhancer ABC_E7528 Neighboring gene STARR-positive B cell enhancer ABC_E1942 Neighboring gene ATPase, H+ transporting, lysosomal V1 subunit G2 Neighboring gene STARR-positive B cell enhancer ABC_E10948 Neighboring gene DEAD box helicase 39b Neighboring gene predicted gene, 22589 Neighboring gene microRNA 6975

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Sequence analysis and expression of a mouse homolog of human IkappaBL gene. Handel-Fernandez ME, et al. Biochim Biophys Acta, 1999 Feb 16. PMID 10023090
  2. NFKBIL1 confers resistance to experimental autoimmune arthritis through the regulation of dendritic cell functions. Chiba T, et al. Scand J Immunol, 2011 May. PMID 21284685
  3. IκBL, a novel member of the nuclear IκB family, inhibits inflammatory cytokine expression. Chiba T, et al. FEBS Lett, 2011 Nov 16. PMID 22024480
  4. A Genome-Wide Association Study for Regulators of Micronucleus Formation in Mice. McIntyre RE, et al. G3 (Bethesda), 2016 Aug 9. PMID 27233670, Free PMC Article
  5. Def-2, -3, -6 and -8, novel mouse genes differentially expressed in the haemopoietic system. Hotfilder M, et al. Br J Haematol, 1999 Aug. PMID 10460589

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. NFKBIL-1 affects the pathogenesis of rheumatoid arthritis at least in part by the regulation of dendritic cell functions.
    Title: NFKBIL1 confers resistance to experimental autoimmune arthritis through the regulation of dendritic cell functions.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables transcription regulator inhibitor activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in cellular response to lipopolysaccharide ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to lipopolysaccharide ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of NF-kappaB transcription factor activity ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of NF-kappaB transcription factor activity ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of canonical NF-kappaB signal transduction IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of lipopolysaccharide-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of lipopolysaccharide-mediated signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of toll-like receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of toll-like receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of toll-like receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of tumor necrosis factor production ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of tumor necrosis factor production ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
NF-kappa-B inhibitor-like protein 1
Names
I-kappa-B-like protein
inhibitor of kappa B-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001364909.1 → NP_001351838.1  NF-kappa-B inhibitor-like protein 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    CR974444
    UniProtKB/TrEMBL
    Q3V006
    Conserved Domains (2) summary
    cd00204
    Location:45 → 115
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:41 → 72
    ANK; ANK repeat [structural motif]

  2. NM_010909.5 → NP_035039.1  NF-kappa-B inhibitor-like protein 1 isoform 1

    See identical proteins and their annotated locations for NP_035039.1

    Status: VALIDATED

    Source sequence(s)
    CR974444
    Consensus CDS
    CCDS28693.1
    UniProtKB/Swiss-Prot
    O88995, Q91X16, Q9R1Y3
    UniProtKB/TrEMBL
    Q3V006
    Related
    ENSMUSP00000035452.7, ENSMUST00000048994.7
    Conserved Domains (4) summary
    cd00204
    Location:69 → 139
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:43 → 110
    Ank_2; Ankyrin repeats (3 copies)
    pfam13857
    Location:84 → 142
    Ank_5; Ankyrin repeats (many copies)
    sd00045
    Location:65 → 96
    ANK; ANK repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    35439151..35455457 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O88995.1 GenPept UniProtKB/Swiss-Prot:O88995

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