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mrp-1 Multidrug resistance-associated protein 1 [ Caenorhabditis elegans ]

Gene ID: 180409, updated on 2-Nov-2024

Summary

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Official Symbol
mrp-1
Official Full Name
Multidrug resistance-associated protein 1
Primary source
WormBase:WBGene00003407
Locus tag
CELE_F57C12.5
See related
AllianceGenome:WB:WBGene00003407
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable ATPase-coupled transmembrane transporter activity. Involved in dauer larval development; regulatory ncRNA-mediated post-transcriptional gene silencing; and stress response to metal ion. Located in plasma membrane. Is expressed in several structures, including intestine; pharyngeal-intestinal valve; rectal valve cell; seam cell; and vulval cell. Human ortholog(s) of this gene implicated in several diseases, including bile duct disease (multiple); bilirubin metabolic disorder (multiple); leukemia (multiple); liver disease (multiple); and lung disease (multiple). Orthologous to several human genes including ABCC3 (ATP binding cassette subfamily C member 3). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See mrp-1 in Genome Data Viewer
Location:
chromosome: X
Exon count:
23
Sequence:
Chromosome: X; NC_003284.9 (576318..587495, complement)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Zinc metalloproteinase nas-38 Neighboring gene Multidrug resistance-associated protein 1 Neighboring gene Bromo domain-containing protein Neighboring gene Neuropeptide-Like Protein;Peptidase_M13 domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Identification of ABC transporters acting in vitamin B(12) metabolism in Caenorhabditis elegans. McDonald MK, et al. Mol Genet Metab, 2017 Dec. PMID 29153845
  2. Reserpine requires the D2-type receptor, dop-3, and the exoribonuclease, eri-1, to extend the lifespan in C. elegans. Saharia K, et al. J Biosci, 2016 Dec. PMID 27966489
  3. Detoxification and sensing mechanisms are of similar importance for Cd resistance in Caenorhabditis elegans. Winter SA, et al. Heliyon, 2016 Oct. PMID 27822562, Free PMC Article
  4. PMK-1 p38 MAPK promotes cadmium stress resistance, the expression of SKN-1/Nrf and DAF-16 target genes, and protein biosynthesis in Caenorhabditis elegans. Keshet A, et al. Mol Genet Genomics, 2017 Dec. PMID 28766017, Free PMC Article
  5. An automated system for measuring parameters of nematode sinusoidal movement. Cronin CJ, et al. BMC Genet, 2005 Feb 7. PMID 15698479, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. MRP-1, through its export activity, supports the induction of the normal life cycle by the insulin signaling pathway.
    Title: Multidrug resistance-associated protein MRP-1 regulates dauer diapause by its export activity in Caenorhabditis elegans.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ABC-type transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables ATPase-coupled transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in dauer larval development IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulatory ncRNA-mediated post-transcriptional gene silencing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in stress response to metal ion IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in stress response to metal ion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in xenobiotic transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Multidrug resistance-associated protein 1
NP_001024719.2
  • Confirmed by transcript evidence
NP_001033553.1
  • Confirmed by transcript evidence
NP_508122.2
  • Confirmed by transcript evidence
NP_741702.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    576318..587495 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_171938.8 → NP_741702.1  Multidrug resistance-associated protein 1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_741702.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q5KQS9, Q8MQ16
    Conserved Domains (5) summary
    TIGR00957
    Location:23 → 1531
    MRP_assoc_pro; multi drug resistance-associated protein (MRP)
    cd03244
    Location:1293 → 1513
    ABCC_MRP_domain2; ATP-binding cassette domain 2 of multidrug resistance-associated protein
    cd03250
    Location:614 → 815
    ABCC_MRP_domain1; ATP-binding cassette domain 1 of multidrug resistance-associated protein, subfamily C
    pfam00664
    Location:976 → 1248
    ABC_membrane; ABC transporter transmembrane region
    cl00549
    Location:309 → 570
    ABC_membrane; ABC transporter transmembrane region

  2. NM_001038464.4 → NP_001033553.1  Multidrug resistance-associated protein 1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001033553.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q3S1M2, Q5KQS9
    Conserved Domains (4) summary
    TIGR00957
    Location:23 → 1531
    MRP_assoc_pro; multi drug resistance-associated protein (MRP)
    cd03244
    Location:1293 → 1513
    ABCC_MRP_domain2; ATP-binding cassette domain 2 of multidrug resistance-associated protein
    cd03250
    Location:614 → 815
    ABCC_MRP_domain1; ATP-binding cassette domain 1 of multidrug resistance-associated protein, subfamily C
    cl00549
    Location:309 → 570
    ABC_membrane; ABC transporter transmembrane region

  3. NM_001029548.6 → NP_001024719.2  Multidrug resistance-associated protein 1 [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7YZW1, Q94136
    Conserved Domains (5) summary
    TIGR00957
    Location:23 → 1531
    MRP_assoc_pro; multi drug resistance-associated protein (MRP)
    cd03244
    Location:1293 → 1513
    ABCC_MRP_domain2; ATP-binding cassette domain 2 of multidrug resistance-associated protein
    cd03250
    Location:614 → 815
    ABCC_MRP_domain1; ATP-binding cassette domain 1 of multidrug resistance-associated protein, subfamily C
    pfam00664
    Location:976 → 1248
    ABC_membrane; ABC transporter transmembrane region
    cl00549
    Location:309 → 570
    ABC_membrane; ABC transporter transmembrane region

  4. NM_075721.10 → NP_508122.2  Multidrug resistance-associated protein 1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_508122.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q5KQS9, Q95QE2
    Conserved Domains (4) summary
    TIGR00957
    Location:23 → 1531
    MRP_assoc_pro; multi drug resistance-associated protein (MRP)
    cd03244
    Location:1293 → 1513
    ABCC_MRP_domain2; ATP-binding cassette domain 2 of multidrug resistance-associated protein
    cd03250
    Location:614 → 815
    ABCC_MRP_domain1; ATP-binding cassette domain 1 of multidrug resistance-associated protein, subfamily C
    cl00549
    Location:976 → 1248
    ABC_membrane; ABC transporter transmembrane region
Nucleotide Protein
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