U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

daf-3 Smad protein daf-3 [ Caenorhabditis elegans ]

Gene ID: 180431, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
daf-3
Official Full Name
Smad protein daf-3
Primary source
WormBase:WBGene00000899
Locus tag
CELE_F25E2.5
See related
AllianceGenome:WB:WBGene00000899
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including defense response to Gram-negative bacterium; determination of adult lifespan; and positive regulation of dauer larval development. Located in condensed chromosome; cytoplasm; and nucleus. Is expressed in several structures, including P1; P10; hermaphrodite distal tip cell; hypodermal cell; and neurons. [provided by Alliance of Genome Resources, Nov 2024]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See daf-3 in Genome Data Viewer
Location:
chromosome: X
Exon count:
15
Sequence:
Chromosome: X; NC_003284.9 (817922..825475, complement)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Intermediate filament protein ifd-2 Neighboring gene ANAPC4_WD40 domain-containing protein Neighboring gene Pericentrin

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. A C. elegans genome-scale microRNA network contains composite feedback motifs with high flux capacity. Martinez NJ, et al. Genes Dev, 2008 Sep 15. PMID 18794350, Free PMC Article
  2. The homeodomain protein hmbx-1 maintains asymmetric gene expression in adult C. elegans olfactory neurons. Lesch BJ, et al. Genes Dev, 2010 Aug 15. PMID 20713521, Free PMC Article
  3. Age-Dependent Neuroendocrine Signaling from Sensory Neurons Modulates the Effect of Dietary Restriction on Longevity of Caenorhabditis elegans. Fletcher M, et al. PLoS Genet, 2017 Jan. PMID 28107363, Free PMC Article
  4. Balancing selection shapes density-dependent foraging behaviour. Greene JS, et al. Nature, 2016 Nov 10. PMID 27799655, Free PMC Article
  5. Developmental programming modulates olfactory behavior in C. elegans via endogenous RNAi pathways. Sims JR, et al. Elife, 2016 Jun 28. PMID 27351255, Free PMC Article

See all (134) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables I-SMAD binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cis-regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in BMP signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in SMAD protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in anatomical structure morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cellular response to pheromone IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in dauer larval development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in defense response to Gram-negative bacterium IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in determination of adult lifespan IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of dauer larval development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in post-embryonic development IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of dauer larval development IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of developmental process IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of multicellular organismal process IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of nematode pharyngeal pumping IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
located_in condensed chromosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
part_of heteromeric SMAD protein complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
Smad protein daf-3
NP_001024604.1
  • Confirmed by transcript evidence
NP_001024605.1
  • Partially confirmed by transcript evidence
NP_001300341.1
  • Confirmed by transcript evidence
NP_001300342.1
  • Confirmed by transcript evidence
NP_001300343.1
  • Confirmed by transcript evidence
NP_001300344.1
  • Confirmed by transcript evidence
NP_001300346.1
  • Confirmed by transcript evidence
NP_001368578.1
  • Confirmed by transcript evidence
NP_508161.3
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    817922..825475 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_075760.6 → NP_508161.3  Smad protein daf-3 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_508161.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A0A0K3ASQ1, A0A0K3ATA0, A0A0K3AVK9, A0A0K3AVL3, A0A0K3AWB3, A0A0K3AYJ4, O17532, Q95QI7, Q95QI8
    Conserved Domains (3) summary
    smart00524
    Location:656 → 857
    DWB; Domain B in dwarfin family proteins
    cd10492
    Location:218 → 343
    MH1_SMAD_4; N-terminal Mad Homology 1 (MH1) domain in SMAD4
    pfam03154
    Location:367 → 557
    Atrophin-1; Atrophin-1 family

  2. NM_001029434.5 → NP_001024605.1  Smad protein daf-3 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001024605.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    O17532
    Conserved Domains (2) summary
    smart00524
    Location:560 → 761
    DWB; Domain B in dwarfin family proteins
    cd10492
    Location:122 → 247
    MH1_SMAD_4; N-terminal Mad Homology 1 (MH1) domain in SMAD4

  3. NM_001313414.4 → NP_001300343.1  Smad protein daf-3 [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0K3AWB3
    Conserved Domains (2) summary
    smart00524
    Location:622 → 823
    DWB; Domain B in dwarfin family proteins
    cd10492
    Location:184 → 309
    MH1_SMAD_4; N-terminal Mad Homology 1 (MH1) domain in SMAD4

  4. NM_001313413.4 → NP_001300342.1  Smad protein daf-3 [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0K3ASQ1
    Conserved Domains (2) summary
    smart00524
    Location:625 → 826
    DWB; Domain B in dwarfin family proteins
    cd10492
    Location:184 → 312
    MH1_SMAD_4; N-terminal Mad Homology 1 (MH1) domain in SMAD4

  5. NM_001029433.7 → NP_001024604.1  Smad protein daf-3 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001024604.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q95QI8
    Conserved Domains (2) summary
    smart00524
    Location:628 → 829
    DWB; Domain B in dwarfin family proteins
    cl00055
    Location:184 → 315
    MH1; N-terminal Mad Homology 1 (MH1) domain

  6. NM_001313412.4 → NP_001300341.1  Smad protein daf-3 [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0K3AVK9
    Conserved Domains (2) summary
    smart00524
    Location:659 → 860
    DWB; Domain B in dwarfin family proteins
    cd10492
    Location:218 → 346
    MH1_SMAD_4; N-terminal Mad Homology 1 (MH1) domain in SMAD4

  7. NM_001380898.1 → NP_001368578.1  Smad protein daf-3 [Caenorhabditis elegans]

    Status: REVIEWED

    Conserved Domains (3) summary
    smart00524
    Location:544 → 745
    DWB; Domain B in dwarfin family proteins
    cd10492
    Location:106 → 231
    MH1_SMAD_4; N-terminal Mad Homology 1 (MH1) domain in SMAD4
    pfam03154
    Location:255 → 445
    Atrophin-1; Atrophin-1 family

  8. NM_001313415.4 → NP_001300344.1  Smad protein daf-3 [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0K3AYJ4
    Conserved Domains (3) summary
    smart00524
    Location:547 → 748
    DWB; Domain B in dwarfin family proteins
    cl00055
    Location:106 → 234
    MH1; N-terminal Mad Homology 1 (MH1) domain
    pfam07223
    Location:249 → 439
    DUF1421; Protein of unknown function (DUF1421)

  9. NM_001313417.4 → NP_001300346.1  Smad protein daf-3 [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0K3AVL3
    Conserved Domains (1) summary
    smart00524
    Location:47 → 248
    DWB; Domain B in dwarfin family proteins
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q95QI7.1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools