lgl-1 Lethal giant larvae homologue 2 domain-containing protein [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: lgl-1
Official Full Name: Lethal giant larvae homologue 2 domain-containing protein
Primary source: WormBase:WBGene00018987
Locus tag: CELE_F56F10.4
See related: AllianceGenome:WB:WBGene00018987
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable GTPase activator activity; myosin II binding activity; and syntaxin binding activity. Involved in establishment of spindle orientation and protein localization. Located in basolateral plasma membrane and cell cortex. Is expressed in epithelial cell; intestine; and spermathecal cell. Orthologous to human LLGL1 (LLGL scribble cell polarity complex component 1) and LLGL2 (LLGL scribble cell polarity complex component 2). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See lgl-1 in Genome Data Viewer

Location:: chromosome: X

Exon count:: 14

Sequence:: Chromosome: X; NC_003284.9 (864097..871089, complement)

Chromosome X - NC_003284.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Upon membrane binding, LGL-1 membrane binding sequence folds into an alpha-helix in which three regions can be identified: a positively charged patch, a switch area containing the three atypical protein kinase C phosphorylation sites, and a hydrophobic area probably buried in the membrane.
Title: In vitro Reconstitution of a Membrane Switch Mechanism for the Polarity Protein LGL.
LGL can partition the cortex of one-cell Caenorhabditis elegans embryos into two domains.
Title: LGL can partition the cortex of one-cell Caenorhabditis elegans embryos into two domains.
Overexpression of LGL-1 is sufficient to rescue loss of PAR-2 function.
Title: The C. elegans homolog of Drosophila Lethal giant larvae functions redundantly with PAR-2 to maintain polarity in the early embryo.
LGL-1 and PAR-2 affect cortical myosin distribution.
Title: PAR-2, LGL-1 and the CDC-42 GAP CHIN-1 act in distinct pathways to maintain polarity in the C. elegans embryo.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F56F10.4 (e-PCR)
- UniSTS:311876

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables GTPase activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables myosin II binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein-containing complex binding	IPI Inferred from Physical Interaction more info	PubMed
enables syntaxin binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in Golgi to plasma membrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in cortical actin cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in establishment of cell polarity	IGI Inferred from Genetic Interaction more info	PubMed
involved_in establishment of spindle orientation	IBA Inferred from Biological aspect of Ancestor more info
involved_in establishment of spindle orientation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in protein localization	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of Notch signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of establishment or maintenance of cell polarity	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in basolateral plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in cell cortex	IDA Inferred from Direct Assay more info	PubMed
is_active_in cortical actin cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Lethal giant larvae homologue 2 domain-containing protein

NP_508169.2

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003284.9 Reference assembly

Range

864097..871089 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_075768.6 → NP_508169.2 Lethal giant larvae homologue 2 domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_508169.2

Status: REVIEWED

UniProtKB/TrEMBL

G5EEI1

Conserved Domains (1) summary

pfam08366
Location:273 → 364

LLGL; LLGL2