unc-1 Band 7 domain-containing protein;Protein unc-1 [Caenorhabditis elegans] - Gene

Summary

Go to the top of the page Help

Official Symbol: unc-1
Official Full Name: Band 7 domain-containing protein;Protein unc-1
Primary source: WormBase:WBGene00006741
Locus tag: CELE_K03E6.5
See related: AllianceGenome:WB:WBGene00006741
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables ion channel regulator activity. Involved in positive regulation of cell communication by electrical coupling and response to xenobiotic stimulus. Located in axon and gap junction. Is expressed in several structures, including enteric muscle; ganglia; head neurons; somatic nervous system; and vulval muscle. [provided by Alliance of Genome Resources, Nov 2024]
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help

See unc-1 in Genome Data Viewer

Location:: chromosome: X

Exon count:: 6

Sequence:: Chromosome: X; NC_003284.9 (1057487..1062453, complement)

Chromosome X - NC_003284.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:: NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Targeted rescue experiments suggest that UNC-9 and UNC-1 function predominantly in neurons to control locomotion.
Title: UNC-1 regulates gap junctions important to locomotion in C. elegans.
unc-1, unc-24, and ssu-1 are neuronal stomatin-like proteins sharing regulatory roles with a sulfotransferase enzyme
Title: Sulfated signal from ASJ sensory neurons modulates stomatin-dependent coordination in Caenorhabditis elegans.
homologues of Hyperkinetic and K channel regulator 1 proteins interact with and modify unc-103 function; effect of mutations on function and physiology
Title: In vivo identification of genes that modify ether-a-go-go-related gene activity in Caenorhabditis elegans may also affect human cardiac arrhythmia.
Mutations in the unc-24 gene alter the distribution of UNC-1 in lipid rafts.
Title: A stomatin and a degenerin interact in lipid rafts of the nervous system of Caenorhabditis elegans.

Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Markers

K03E6.5 (e-PCR)
- UniSTS:320323

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables ion channel regulator activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in positive regulation of cell communication by electrical coupling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to xenobiotic stimulus	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in axon	IDA Inferred from Direct Assay more info	PubMed
located_in cell-cell junction	IDA Inferred from Direct Assay more info	PubMed
located_in gap junction	IDA Inferred from Direct Assay more info	PubMed
located_in gap junction	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

Go to the top of the page Help

Preferred Names: Band 7 domain-containing protein;Protein unc-1

NP_001123162.1

Confirmed by transcript evidence

NP_508202.1

Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003284.9 Reference assembly

Range

1057487..1062453 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001129690.5 → NP_001123162.1 Band 7 domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001123162.1

Status: REVIEWED

UniProtKB/TrEMBL

G5ED08

Conserved Domains (1) summary

cl19107
Location:79 → 279

SPFH_like; core domain of the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily
NM_075801.7 → NP_508202.1 Protein unc-1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_508202.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q21190

Conserved Domains (2) summary

smart00244
Location:54 → 203

PHB; prohibitin homologues

cl19107
Location:75 → 275

SPFH_like; core domain of the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily