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lmp-2 Lysosome-associated membrane glycoprotein 5 [ Caenorhabditis elegans ]

Gene ID: 180467, updated on 2-Nov-2024

Summary

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Official Symbol
lmp-2
Official Full Name
Lysosome-associated membrane glycoprotein 5
Primary source
WormBase:WBGene00015471
Locus tag
CELE_C05D9.2
See related
AllianceGenome:WB:WBGene00015471
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to be involved in establishment of protein localization to organelle. Predicted to be located in membrane. Predicted to be active in late endosome membrane; lysosomal membrane; and plasma membrane. Is expressed in intestine. Orthologous to human LAMP1 (lysosomal associated membrane protein 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See lmp-2 in Genome Data Viewer
Location:
chromosome: X
Exon count:
8
Sequence:
Chromosome: X; NC_003284.9 (1125615..1128288)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene TransThyretin-Related family domain;WG repeat-containing protein Neighboring gene PX domain-containing protein Neighboring gene VWFA domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Inhibition of chaperone-mediated autophagy prevents glucotoxicity in the Caenorhabditis elegans mev-1 mutant by activation of the proteasome. Eisermann DJ, et al. Biochem Biophys Res Commun, 2017 Feb 26. PMID 28089866
  2. The lysosomal membrane protein SCAV-3 maintains lysosome integrity and adult longevity. Li Y, et al. J Cell Biol, 2016 Oct 24. PMID 27810910, Free PMC Article
  3. UNC-46 is required for trafficking of the vesicular GABA transporter. Schuske K, et al. Nat Neurosci, 2007 Jul. PMID 17558401
  4. Decreased insulin-receptor signaling promotes the autophagic degradation of beta-amyloid peptide in C. elegans. Florez-McClure ML, et al. Autophagy, 2007 Nov-Dec. PMID 17675890
  5. Lysosome activity is modulated by multiple longevity pathways and is important for lifespan extension in C. elegans. Sun Y, et al. Elife, 2020 Jun 2. PMID 32482227, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Process Evidence Code Pubs
involved_in establishment of protein localization to organelle IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in late endosome membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in lysosomal membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Lysosome-associated membrane glycoprotein 5
NP_001379622.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    1125615..1128288
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001392725.1 → NP_001379622.1  Lysosome-associated membrane glycoprotein 5 [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9GYK0
    Conserved Domains (1) summary
    pfam01299
    Location:29 → 214
    Lamp; Lysosome-associated membrane glycoprotein (Lamp)
Nucleotide Protein
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