toca-1 Transducer of Cdc42-dependent actin assembly protein 1 homolog [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: toca-1
Official Full Name: Transducer of Cdc42-dependent actin assembly protein 1 homolog
Primary source: WormBase:WBGene00017298
Locus tag: CELE_F09E10.8
See related: AllianceGenome:WB:WBGene00017298
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Involved in several processes, including negative regulation of protein localization to adherens junction; positive regulation of clathrin-dependent endocytosis; and positive regulation of egg-laying behavior. Located in cell-cell junction; intracellular vesicle; and plasma membrane. Is expressed in anchor cell and vulF. Orthologous to human FNBP1 (formin binding protein 1); FNBP1L (formin binding protein 1 like); and TRIP10 (thyroid hormone receptor interactor 10). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See toca-1 in Genome Data Viewer

Location:: chromosome: X

Exon count:: 8

Sequence:: Chromosome: X; NC_003284.9 (1510481..1521487, complement)

Chromosome X - NC_003284.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

toca-1 is in a novel pathway that functions in parallel with a SUN-KASH nuclear envelope bridge to move nuclei in Caenorhabditis elegans.
Title: toca-1 is in a novel pathway that functions in parallel with a SUN-KASH nuclear envelope bridge to move nuclei in Caenorhabditis elegans.
TOCA-1 and TOCA-2 are important for the regulation of Clathrin-mediated endocytic processes during oocyte growth, and in the control of epithelial morphogenesis in developing embryos.
Title: Requirements for F-BAR proteins TOCA-1 and TOCA-2 in actin dynamics and membrane trafficking during Caenorhabditis elegans oocyte growth and embryonic epidermal morphogenesis.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F09E10.8 (e-PCR)
- UniSTS:315233

F09E10.9 (e-PCR)
- UniSTS:319225

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in embryonic ectodermal digestive tract morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in embryonic ectodermal digestive tract morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in endocytosis	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of protein localization to adherens junction	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of clathrin-dependent endocytosis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of clathrin-dependent endocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of egg-laying behavior	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of actin cytoskeleton organization	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in anchoring junction	IEA Inferred from Electronic Annotation more info
located_in apical plasma membrane	IEA Inferred from Electronic Annotation more info
located_in basolateral plasma membrane	IEA Inferred from Electronic Annotation more info
located_in cell-cell junction	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in endosome	IEA Inferred from Electronic Annotation more info
located_in intracellular vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in recycling endosome	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Transducer of Cdc42-dependent actin assembly protein 1 homolog

NP_741723.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003284.9 Reference assembly

Range

1510481..1521487 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_171940.8 → NP_741723.1 Transducer of Cdc42-dependent actin assembly protein 1 homolog [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_741723.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q19253, Q8MQ82

Conserved Domains (3) summary

cd07653
Location:8 → 259

F-BAR_CIP4-like; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Cdc42-Interacting Protein 4 and similar proteins

cd11619
Location:362 → 438

HR1_CIP4-like; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Cdc42-Interacting Protein 4 and similar proteins

cd11911
Location:532 → 586

SH3_CIP4-like; Src Homology 3 domain of Cdc42-Interacting Protein 4