U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

hex-1 Beta-hexosaminidase A [ Caenorhabditis elegans ]

Gene ID: 180533, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
hex-1
Official Full Name
Beta-hexosaminidase A
Primary source
WormBase:WBGene00020509
Locus tag
CELE_T14F9.3
See related
AllianceGenome:WB:WBGene00020509
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables beta-N-acetylhexosaminidase activity. Involved in carbohydrate metabolic process. Predicted to be active in lysosome and membrane. Is expressed in body wall musculature; coelomocyte; head mesodermal cell; nervous system; and pharynx. Human ortholog(s) of this gene implicated in Sandhoff disease; Tay-Sachs disease; and spinal muscular atrophy. Orthologous to human HEXA (hexosaminidase subunit alpha) and HEXB (hexosaminidase subunit beta). [provided by Alliance of Genome Resources, Nov 2024]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See hex-1 in Genome Data Viewer
Location:
chromosome: X
Exon count:
10
Sequence:
Chromosome: X; NC_003284.9 (2223484..2226620)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene FLYWCH-type zinc finger-containing protein peb-1 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene tRNA-Asp

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. N-glycan antennal modifications are altered in Caenorhabditis elegans lacking the HEX-4 N-acetylgalactosamine-specific hexosaminidase. Paschinger K, et al. J Biol Chem, 2023 Apr. PMID 36813232, Free PMC Article
  2. Biosynthesis of truncated N-linked oligosaccharides results from non-orthologous hexosaminidase-mediated mechanisms in nematodes, plants, and insects. Gutternigg M, et al. J Biol Chem, 2007 Sep 21. PMID 17636254, Free PMC Article
  3. C. elegans BLMP-1 controls apical epidermal cell morphology by repressing expression of mannosyltransferase bus-8 and molting signal mlt-8. Wu YZ, et al. Dev Biol, 2022 Jun. PMID 35367457
  4. Lysosome activity is modulated by multiple longevity pathways and is important for lifespan extension in C. elegans. Sun Y, et al. Elife, 2020 Jun 2. PMID 32482227, Free PMC Article
  5. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

Go to the top of the page

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables beta-N-acetylhexosaminidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables beta-N-acetylhexosaminidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables beta-N-acetylhexosaminidase activity IEA
Inferred from Electronic Annotation
more info
  
enables hexosaminidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables hydrolase activity, acting on glycosyl bonds IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity, hydrolyzing O-glycosyl compounds IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in N-glycan processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in carbohydrate metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in glycosaminoglycan metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
is_active_in lysosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in lysosome IEA
Inferred from Electronic Annotation
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
Beta-hexosaminidase A
NP_508409.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    2223484..2226620
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_076008.8 → NP_508409.1  Beta-hexosaminidase A [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_508409.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A7DY65, Q22492
    Conserved Domains (2) summary
    cd06562
    Location:170 → 529
    GH20_HexA_HexB-like; Beta-N-acetylhexosaminidases catalyze the removal of beta-1,4-linked N-acetyl-D-hexosamine residues from the non-reducing ends of N-acetyl-beta-D-hexosaminides including N-acetylglucosides and N-acetylgalactosides. The hexA and hexB genes encode the ...
    cl03741
    Location:99 → 147
    Glyco_hydro_20b; Glycosyl hydrolase family 20, domain 2
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q22492.1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous