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hid-1 Protein HID1 [ Caenorhabditis elegans ]

Gene ID: 180553, updated on 2-Nov-2024

Summary

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Official Symbol
hid-1
Official Full Name
Protein HID1
Primary source
WormBase:WBGene00001844
Locus tag
CELE_K02E10.2
See related
AllianceGenome:WB:WBGene00001844
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Involved in several processes, including cellular response to carbon dioxide; defecation; and negative regulation of nematode pharyngeal pumping. Located in several cellular components, including Golgi cisterna; cytosol; and neuron projection. Is expressed in intestine; nervous system; pharynx; and uv1. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 105. Orthologous to human HID1 (HID1 domain containing). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See hid-1 in Genome Data Viewer
Location:
chromosome: X
Exon count:
15
Sequence:
Chromosome: X; NC_003284.9 (2489048..2494339)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene CX domain-containing protein Neighboring gene Uncharacterized protein Neighboring gene RAB family Neighboring gene ncRNA Neighboring gene Protein kinase domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. HID-1 is a novel player in the regulation of neuropeptide sorting. Yu Y, et al. Biochem J, 2011 Mar 15. PMID 21250940
  2. HID-1 is a peripheral membrane protein primarily associated with the medial- and trans- Golgi apparatus. Wang L, et al. Protein Cell, 2011 Jan. PMID 21337012, Free PMC Article
  3. HID-1, a new component of the peptidergic signaling pathway. Mesa R, et al. Genetics, 2011 Feb. PMID 21115972, Free PMC Article
  4. The flight response impairs cytoprotective mechanisms by activating the insulin pathway. De Rosa MJ, et al. Nature, 2019 Sep. PMID 31462774, Free PMC Article
  5. The response to high CO2 levels requires the neuropeptide secretion component HID-1 to promote pumping inhibition. Sharabi K, et al. PLoS Genet, 2014 Aug. PMID 25101962, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in cellular response to carbon dioxide IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in dauer larval development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in defecation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in locomotion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of nematode pharyngeal pumping IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of peptide secretion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to heat IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in Golgi medial cisterna IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi medial cisterna IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in Golgi trans cisterna IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi trans cisterna IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in neuron projection IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Protein HID1
NP_001024748.1
  • Confirmed by transcript evidence
NP_001024749.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    2489048..2494339
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001029577.4 → NP_001024748.1  Protein HID1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001024748.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5EG65
    Conserved Domains (1) summary
    pfam12722
    Location:1 → 726
    Hid1; High-temperature-induced dauer-formation protein

  2. NM_001029578.5 → NP_001024749.1  Protein HID1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001024749.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7Z135
    Conserved Domains (1) summary
    pfam12722
    Location:1 → 708
    Hid1; High-temperature-induced dauer-formation protein
Nucleotide Protein
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