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nhr-40 Nuclear hormone receptor family member nhr-40 [ Caenorhabditis elegans ]

Gene ID: 180560, updated on 18-Sep-2024

Summary

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Official Symbol
nhr-40
Official Full Name
Nuclear hormone receptor family member nhr-40
Primary source
WormBase:WBGene00003630
Locus tag
CELE_T03G6.2
See related
AllianceGenome:WB:WBGene00003630
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable RNA polymerase II cis-regulatory region sequence-specific DNA binding activity and nuclear receptor activity. Predicted to be involved in anatomical structure development; cell differentiation; and regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Is expressed in several structures, including P1; P10; P11; egg-laying apparatus; and somatic nervous system. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See nhr-40 in Genome Data Viewer
Location:
chromosome: X
Exon count:
13
Sequence:
Chromosome: X; NC_003284.9 (2594003..2606732)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Uncharacterized protein Neighboring gene YitH/HolE acetyltransferase (GNAT) domain-containing protein Neighboring gene glycerophosphocholine cholinephosphodiesterase Neighboring gene tRNA-Gly

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. NHR-40, a Caenorhabditis elegans supplementary nuclear receptor, regulates embryonic and early larval development. Brozová E, et al. Mech Dev, 2006 Sep. PMID 16920335
  2. Conserved nuclear hormone receptors controlling a novel plastic trait target fast-evolving genes expressed in a single cell. Sieriebriennikov B, et al. PLoS Genet, 2020 Apr. PMID 32282814, Free PMC Article
  3. Proteomic analysis uncovers a metabolic phenotype in C. elegans after nhr-40 reduction of function. Pohludka M, et al. Biochem Biophys Res Commun, 2008 Sep 12. PMID 18616929, Free PMC Article
  4. Transcriptional regulation. Okkema PG, et al. WormBook, 2005 Dec 23. PMID 18050428, Free PMC Article
  5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. NHR-40 provides a link between metabolism and muscle development.
    Title: Proteomic analysis uncovers a metabolic phenotype in C. elegans after nhr-40 reduction of function.
  2. The nhr-40 loss of function phenotype includes irregular development of body wall muscle cells and impaired movement and coordination resembling neuromuscular affection.
    Title: NHR-40, a Caenorhabditis elegans supplementary nuclear receptor, regulates embryonic and early larval development.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nuclear receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Nuclear hormone receptor family member nhr-40
NP_001024873.1
  • Confirmed by transcript evidence
NP_001362027.1
  • Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    2594003..2606732
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001029702.5 → NP_001024873.1  Nuclear hormone receptor family member nhr-40 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001024873.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q22127
    Conserved Domains (2) summary
    cd06960
    Location:15 → 90
    NR_DBD_HNF4A; DNA-binding domain of heptocyte nuclear factor 4 (HNF4) is composed of two C4-type zinc fingers
    smart00430
    Location:230 → 405
    HOLI; Ligand binding domain of hormone receptors

  2. NM_001374979.2 → NP_001362027.1  Nuclear hormone receptor family member nhr-40 [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q22127, Q8MPY4, Q9GTH6
    Conserved Domains (2) summary
    cd06960
    Location:31 → 106
    NR_DBD_HNF4A; DNA-binding domain of heptocyte nuclear factor 4 (HNF4) is composed of two C4-type zinc fingers
    smart00430
    Location:246 → 421
    HOLI; Ligand binding domain of hormone receptors
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q22127.4

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