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unc-2 EF-hand domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 180570, updated on 2-Nov-2024

Summary

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Official Symbol
unc-2
Official Full Name
EF-hand domain-containing protein
Primary source
WormBase:WBGene00006742
Locus tag
CELE_T02C5.5
See related
AllianceGenome:WB:WBGene00006742
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable high voltage-gated calcium channel activity. Involved in several processes, including determination of left/right asymmetry in nervous system; negative regulation of transforming growth factor beta receptor signaling pathway; and response to heat. Located in presynaptic active zone membrane. Is expressed in several structures, including body wall musculature; excretory canal; head; neurons; and pharyngeal muscle cell. Used to study migraine. Human ortholog(s) of this gene implicated in Lambert-Eaton myasthenic syndrome; developmental and epileptic encephalopathy (multiple); hereditary ataxia (multiple); and migraine (multiple). Orthologous to several human genes including CACNA1B (calcium voltage-gated channel subunit alpha1 B). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See unc-2 in Genome Data Viewer
Location:
chromosome: X
Exon count:
40
Sequence:
Chromosome: X; NC_003284.9 (2710920..2763526, complement)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Membrane-associated protein Neighboring gene TNFR-Cys domain-containing protein Neighboring gene Ig-like domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Gain-of-function mutations in the UNC-2/CaV2α channel lead to excitation-dominant synaptic transmission in Caenorhabditis elegans. Huang YC, et al. Elife, 2019 Aug 5. PMID 31364988, Free PMC Article
  2. Invertebrate modeling of a migraine channelopathy. Estevez M. Headache, 2006 Jun. PMID 16927961
  3. Age-associated changes to neuronal dynamics involve a disruption of excitatory/inhibitory balance in C. elegans. Wirak GS, et al. Elife, 2022 Jun 15. PMID 35703498, Free PMC Article
  4. Critical residues of the Caenorhabditis elegans unc-2 voltage-gated calcium channel that affect behavioral and physiological properties. Mathews EA, et al. J Neurosci, 2003 Jul 23. PMID 12878695, Free PMC Article
  5. The nematode neuropeptide, AF2 (KHEYLRF-NH2), increases voltage-activated calcium currents in Ascaris suum muscle. Verma S, et al. Br J Pharmacol, 2007 Jul. PMID 17519945, Free PMC Article

See all (113) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. These studies reveal mechanisms through which UNC2 gain-of-function mutations disrupt excitation-inhibition balance in the nervous system.
    Title: Gain-of-function mutations in the UNC-2/CaV2α channel lead to excitation-dominant synaptic transmission in Caenorhabditis elegans.
  2. SLO-1 and SLO-2 localize close to UNC-2 and EGL-19 in AWC, suggesting a role of possible functional coupling between SLO BK channels and voltage-activated calcium channels in AWC asymmetry.
    Title: SLO BK Potassium Channels Couple Gap Junctions to Inhibition of Calcium Signaling in Olfactory Neuron Diversification.
  3. UNC-2 calcium channels that provide calcium ions for neurotransmitter release influence the localization specificity of the SLO-1 channel clusters at presynaptic terminals
    Title: Presynaptic BK channel localization is dependent on the hierarchical organization of alpha-catulin and dystrobrevin and fine-tuned by CaV2 calcium channels.
  4. identified UNC-2/UNC-36 voltage-gated calcium channels and UNC-43/CaMKII as regulators of C. elegans synaptogenesis
    Title: The Caenorhabditis elegans voltage-gated calcium channel subunits UNC-2 and UNC-36 and the calcium-dependent kinase UNC-43/CaMKII regulate neuromuscular junction morphology.
  5. UNC-2 plays a pivotal role in mediating a number of physiological processes in the nematode; mutational analysis revealed critical residues important for calcium channel function in vivo
    Title: Critical residues of the Caenorhabditis elegans unc-2 voltage-gated calcium channel that affect behavioral and physiological properties.
  6. Transgenic expression of the migraine-associated Ca2+ channel, CACNA1A, in unc-2 animals can functionally substitute for UNC-2 in stress-activated regulation of tryptophan hydroxylase expression
    Title: The voltage-gated calcium channel UNC-2 is involved in stress-mediated regulation of tryptophan hydroxylase.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables calcium channel activity IEA
Inferred from Electronic Annotation
more info
  
enables high voltage-gated calcium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables monoatomic ion channel activity IEA
Inferred from Electronic Annotation
more info
  
enables voltage-gated calcium channel activity IEA
Inferred from Electronic Annotation
more info
  
enables voltage-gated calcium channel activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
involved_in calcium ion import across plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in calcium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in calcium ion transmembrane transport ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in chemical synaptic transmission IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in determination of left/right asymmetry in nervous system IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in determination of left/right asymmetry in nervous system IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in locomotory behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of transforming growth factor beta receptor signaling pathway IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in response to heat IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to starvation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
part_of monoatomic ion channel complex IEA
Inferred from Electronic Annotation
more info
  
located_in presynaptic active zone membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in synapse IEA
Inferred from Electronic Annotation
more info
  
part_of voltage-gated calcium channel complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of voltage-gated calcium channel complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
EF-hand domain-containing protein
NP_001335515.1
  • Confirmed by transcript evidence
NP_001335516.1
  • Confirmed by transcript evidence
NP_001335560.1
  • Confirmed by transcript evidence
NP_001335561.1
  • Confirmed by transcript evidence
NP_001335562.1
  • Confirmed by transcript evidence
NP_001335563.1
  • Confirmed by transcript evidence
NP_001335570.1
  • Partially confirmed by transcript evidence
NP_001335571.1
  • Partially confirmed by transcript evidence
NP_001335572.1
  • Partially confirmed by transcript evidence
NP_001335573.1
  • Partially confirmed by transcript evidence
NP_001355462.1
  • Partially confirmed by transcript evidence
NP_001355463.1
  • Partially confirmed by transcript evidence
NP_001355464.1
  • Partially confirmed by transcript evidence
NP_001355494.1
  • Partially confirmed by transcript evidence
NP_741732.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    2710920..2763526 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_171638.3 → NP_741732.2  EF-hand domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_741732.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q86G45, Q8MPY6
    Conserved Domains (3) summary
    pfam00520
    Location:1179 → 1433
    Ion_trans; Ion transport protein
    pfam08763
    Location:1506 → 1582
    Ca_chan_IQ; Voltage gated calcium channel IQ domain
    pfam16905
    Location:1442 → 1495
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated

  2. NM_001348592.5 → NP_001335571.1  EF-hand domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1N7SYU4
    Conserved Domains (4) summary
    pfam05539
    Location:1885 → 2042
    Pneumo_att_G; Pneumovirinae attachment membrane glycoprotein G
    pfam00520
    Location:1201 → 1455
    Ion_trans; Ion transport protein
    pfam08763
    Location:1528 → 1604
    Ca_chan_IQ; Voltage gated calcium channel IQ domain
    pfam16905
    Location:1464 → 1517
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated

  3. NM_001348596.5 → NP_001335516.1  EF-hand domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8MPY5
    Conserved Domains (3) summary
    pfam00520
    Location:1045 → 1299
    Ion_trans; Ion transport protein
    pfam08763
    Location:1372 → 1448
    Ca_chan_IQ; Voltage gated calcium channel IQ domain
    pfam16905
    Location:1308 → 1361
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated

  4. NM_001348594.5 → NP_001335570.1  EF-hand domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1N7SYU0
    Conserved Domains (4) summary
    pfam05539
    Location:1903 → 2060
    Pneumo_att_G; Pneumovirinae attachment membrane glycoprotein G
    pfam00520
    Location:1201 → 1455
    Ion_trans; Ion transport protein
    pfam08763
    Location:1528 → 1604
    Ca_chan_IQ; Voltage gated calcium channel IQ domain
    pfam16905
    Location:1464 → 1517
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated

  5. NM_001368494.4 → NP_001355464.1  EF-hand domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A3B1E663
    Conserved Domains (3) summary
    pfam00520
    Location:1323 → 1577
    Ion_trans; Ion transport protein
    pfam08763
    Location:1650 → 1726
    Ca_chan_IQ; Voltage gated calcium channel IQ domain
    pfam16905
    Location:1586 → 1639
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated

  6. NM_001368495.4 → NP_001355463.1  EF-hand domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A3B1DR32
    Conserved Domains (3) summary
    pfam00520
    Location:1271 → 1525
    Ion_trans; Ion transport protein
    pfam08763
    Location:1598 → 1674
    Ca_chan_IQ; Voltage gated calcium channel IQ domain
    pfam16905
    Location:1534 → 1587
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated

  7. NM_001368496.4 → NP_001355462.1  EF-hand domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A3B1E4Z9
    Conserved Domains (3) summary
    pfam00520
    Location:1279 → 1533
    Ion_trans; Ion transport protein
    pfam08763
    Location:1606 → 1682
    Ca_chan_IQ; Voltage gated calcium channel IQ domain
    pfam16905
    Location:1542 → 1595
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated

  8. NM_001348588.4 → NP_001335561.1  EF-hand domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1N7SYT0
    Conserved Domains (4) summary
    pfam05539
    Location:1820 → 1977
    Pneumo_att_G; Pneumovirinae attachment membrane glycoprotein G
    pfam00520
    Location:1136 → 1390
    Ion_trans; Ion transport protein
    pfam08763
    Location:1463 → 1539
    Ca_chan_IQ; Voltage gated calcium channel IQ domain
    pfam16905
    Location:1399 → 1452
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated

  9. NM_001348589.4 → NP_001335563.1  EF-hand domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1N7SYU6
    Conserved Domains (3) summary
    pfam00520
    Location:1136 → 1390
    Ion_trans; Ion transport protein
    pfam08763
    Location:1463 → 1539
    Ca_chan_IQ; Voltage gated calcium channel IQ domain
    pfam16905
    Location:1399 → 1452
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated

  10. NM_001348590.4 → NP_001335560.1  EF-hand domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1N7SYV5
    Conserved Domains (4) summary
    pfam05539
    Location:1838 → 1995
    Pneumo_att_G; Pneumovirinae attachment membrane glycoprotein G
    pfam00520
    Location:1136 → 1390
    Ion_trans; Ion transport protein
    pfam08763
    Location:1463 → 1539
    Ca_chan_IQ; Voltage gated calcium channel IQ domain
    pfam16905
    Location:1399 → 1452
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated

  11. NM_001348591.4 → NP_001335562.1  EF-hand domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1N7SYT1
    Conserved Domains (3) summary
    pfam00520
    Location:1136 → 1390
    Ion_trans; Ion transport protein
    pfam08763
    Location:1463 → 1539
    Ca_chan_IQ; Voltage gated calcium channel IQ domain
    pfam16905
    Location:1399 → 1452
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated

  12. NM_001348593.4 → NP_001335573.1  EF-hand domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1N7SYT8
    Conserved Domains (3) summary
    pfam00520
    Location:1201 → 1455
    Ion_trans; Ion transport protein
    pfam08763
    Location:1528 → 1604
    Ca_chan_IQ; Voltage gated calcium channel IQ domain
    pfam16905
    Location:1464 → 1517
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated

  13. NM_001348595.4 → NP_001335572.1  EF-hand domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1N7SYV7
    Conserved Domains (3) summary
    pfam00520
    Location:1201 → 1455
    Ion_trans; Ion transport protein
    pfam08763
    Location:1528 → 1604
    Ca_chan_IQ; Voltage gated calcium channel IQ domain
    pfam16905
    Location:1464 → 1517
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated

  14. NM_001368497.5 → NP_001355494.1  EF-hand domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A3B1E695
    Conserved Domains (3) summary
    pfam00520
    Location:1137 → 1391
    Ion_trans; Ion transport protein
    pfam08763
    Location:1464 → 1540
    Ca_chan_IQ; Voltage gated calcium channel IQ domain
    pfam16905
    Location:1400 → 1453
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated

  15. NM_001348597.2 → NP_001335515.1  EF-hand domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5EFB0
    Conserved Domains (3) summary
    pfam00520
    Location:1045 → 1299
    Ion_trans; Ion transport protein
    pfam08763
    Location:1372 → 1448
    Ca_chan_IQ; Voltage gated calcium channel IQ domain
    pfam16905
    Location:1308 → 1361
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated
Nucleotide Protein
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