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cnnm-3 Metal transporter cnnm-3 [ Caenorhabditis elegans ]

Gene ID: 180591, updated on 2-Nov-2024

Summary

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Official Symbol
cnnm-3
Official Full Name
Metal transporter cnnm-3
Primary source
WormBase:WBGene00016343
Locus tag
CELE_C33D12.2
See related
AllianceGenome:WB:WBGene00016343
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable transmembrane transporter activity. Involved in several processes, including determination of adult lifespan; magnesium ion homeostasis; and positive regulation of vulval development. Located in basolateral plasma membrane. Is expressed in several structures, including intestine; nervous system; pharynx; rectum; and vulval muscle. Human ortholog(s) of this gene implicated in Jalili syndrome and renal hypomagnesemia 6. Orthologous to several human genes including CNNM1 (cyclin and CBS domain divalent metal cation transport mediator 1); CNNM2 (cyclin and CBS domain divalent metal cation transport mediator 2); and CNNM3 (cyclin and CBS domain divalent metal cation transport mediator 3). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See cnnm-3 in Genome Data Viewer
Location:
chromosome: X
Exon count:
15
Sequence:
Chromosome: X; NC_003284.9 (3036427..3045847, complement)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene tRNA-Glu Neighboring gene tRNA-Gly Neighboring gene ncRNA Neighboring gene Potassium channel domain-containing protein Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Excessive Mg(2+) Impairs Intestinal Homeostasis by Enhanced Production of Adenosine Triphosphate and Reactive Oxygen Species. Hashizume O, et al. Antioxid Redox Signal, 2020 Jul 1. PMID 32148064
  2. Intestinal Mg(2+) accumulation induced by cnnm mutations decreases the body size by suppressing TORC2 signaling in Caenorhabditis elegans. Hashizume O, et al. Dev Biol, 2024 May. PMID 38373693
  3. Mg2+ Extrusion from Intestinal Epithelia by CNNM Proteins Is Essential for Gonadogenesis via AMPK-TORC1 Signaling in Caenorhabditis elegans. Ishii T, et al. PLoS Genet, 2016 Aug. PMID 27564576, Free PMC Article
  4. The Oncogenic PRL Protein Causes Acid Addiction of Cells by Stimulating Lysosomal Exocytosis. Funato Y, et al. Dev Cell, 2020 Nov 23. PMID 32918875
  5. A conserved role for a GATA transcription factor in regulating epithelial innate immune responses. Shapira M, et al. Proc Natl Acad Sci U S A, 2006 Sep 19. PMID 16968778, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in determination of adult lifespan IEA
Inferred from Electronic Annotation
more info
  
involved_in determination of adult lifespan IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in determination of adult lifespan IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in innate immune response HEP PubMed 
involved_in magnesium ion homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in magnesium ion homeostasis IEA
Inferred from Electronic Annotation
more info
  
involved_in magnesium ion homeostasis IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in magnesium ion transport IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of gonad development IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of gonad development IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of multicellular organism growth IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of vulval development IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in response to magnesium ion IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in basolateral plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in basolateral plasma membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Metal transporter cnnm-3
NP_001309670.1
  • Confirmed by transcript evidence
NP_001368594.1
  • Partially confirmed by transcript evidence
NP_001370534.1
  • Confirmed by transcript evidence
NP_001370952.1
  • Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    3036427..3045847 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001322613.3 → NP_001309670.1  Metal transporter cnnm-3 [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A0A131MBV5, A0A131MCZ8, A0A131MD56, Q21469
    Conserved Domains (2) summary
    pfam01595
    Location:199 → 366
    DUF21; Domain of unknown function DUF21
    cl15354
    Location:398 → 491
    CBS_pair; The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called ...

  2. NM_001383538.1 → NP_001370534.1  Metal transporter cnnm-3 [Caenorhabditis elegans]

    Status: REVIEWED

    Conserved Domains (1) summary
    cl40423
    Location:85 → 112
    cupin_RmlC-like; RmlC-like cupin superfamily

  3. NM_001383539.1 → NP_001370952.1  Metal transporter cnnm-3 [Caenorhabditis elegans]

    Status: REVIEWED

    Conserved Domains (1) summary
    COG1253
    Location:198 → 491
    TlyC; Hemolysin or related protein, contains CBS domains [General function prediction only]

  4. NM_001380926.1 → NP_001368594.1  Metal transporter cnnm-3 [Caenorhabditis elegans]

    Status: REVIEWED

    Conserved Domains (1) summary
    cl40423
    Location:85 → 112
    cupin_RmlC-like; RmlC-like cupin superfamily
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A131MCZ8.1

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