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gpd-3 Glyceraldehyde-3-phosphate dehydrogenase 3 [ Caenorhabditis elegans ]

Gene ID: 180601, updated on 2-Nov-2024

Summary

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Official Symbol
gpd-3
Official Full Name
Glyceraldehyde-3-phosphate dehydrogenase 3
Primary source
WormBase:WBGene00001685
Locus tag
CELE_K10B3.7
See related
AllianceGenome:WB:WBGene00001685
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity. Predicted to be involved in glycolytic process. Predicted to be located in cytoplasm. Predicted to be active in cytosol. Is expressed in several structures, including gonad; intestine; and pharynx. Human ortholog(s) of this gene implicated in Alzheimer's disease. Orthologous to human GAPDH (glyceraldehyde-3-phosphate dehydrogenase). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See gpd-3 in Genome Data Viewer
Location:
chromosome: X
Exon count:
3
Sequence:
Chromosome: X; NC_003284.9 (3112091..3113341, complement)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene C2H2-type domain-containing protein Neighboring gene ncRNA Neighboring gene Putative glycerophosphocholine phosphodiesterase GPCPD1 homolog 1 Neighboring gene Glyceraldehyde-3-phosphate dehydrogenase 2 Neighboring gene ATPase inhibitor mai-1, mitochondrial

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Functional analysis of a C. elegans trans-splice acceptor. Conrad R, et al. Nucleic Acids Res, 1993 Feb 25. PMID 8451190, Free PMC Article
  2. Interplay between AAUAAA and the trans-splice site in processing of a Caenorhabditis elegans operon pre-mRNA. Liu Y, et al. RNA, 2001 Feb. PMID 11233975, Free PMC Article
  3. Relationship between 3' end formation and SL2-specific trans-splicing in polycistronic Caenorhabditis elegans pre-mRNA processing. Kuersten S, et al. RNA, 1997 Mar. PMID 9056764, Free PMC Article
  4. Two isoenzymes of glyceraldehyde-3-phosphate dehydrogenase in Caenorhabditis elegans. Isolation, properties, and immunochemical characterization. Yarbrough PO, et al. J Biol Chem, 1984 Dec 10. PMID 6389551
  5. Cloning of a trans-spliced glyceraldehyde-3-phosphate-dehydrogenase gene from the potato cyst nematode Globodera rostochiensis and expression of its putative promoter region in Caenorhabditis elegans. Qin L, et al. Mol Biochem Parasitol, 1998 Oct 30. PMID 9851607

See all (52) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The daf-2-enhanced anoxia phenotype is dependent upon the gpd-2 and gpd-3 genes in an operon that encodes GPD.
    Title: Glyceraldehyde-3-phosphate dehydrogenase mediates anoxia response and survival in Caenorhabditis elegans.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables NAD binding IEA
Inferred from Electronic Annotation
more info
  
enables NADP binding IEA
Inferred from Electronic Annotation
more info
  
enables glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in glucose metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in glycolytic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glycolytic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Glyceraldehyde-3-phosphate dehydrogenase 3
NP_508534.3
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    3112091..3113341 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_076133.9 → NP_508534.3  Glyceraldehyde-3-phosphate dehydrogenase 3 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_508534.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P17330
    Conserved Domains (1) summary
    PLN02272
    Location:3 → 338
    PLN02272; glyceraldehyde-3-phosphate dehydrogenase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P17330.1

Gene LinkOut

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