klp-4 Kinesin motor domain-containing protein [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: klp-4
Official Full Name: Kinesin motor domain-containing protein
Primary source: WormBase:WBGene00002217
Locus tag: CELE_F56E3.3
See related: AllianceGenome:WB:WBGene00002217
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable ATP hydrolysis activity; microtubule binding activity; and microtubule motor activity. Predicted to be involved in vesicle transport along microtubule. Located in axon; cytoplasmic microtubule; and neuronal cell body. Is expressed in distal tip cell; head; intestine; nervous system; and pharynx. Orthologous to human KIF13A (kinesin family member 13A) and KIF13B (kinesin family member 13B). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See klp-4 in Genome Data Viewer

Location:: chromosome: X

Exon count:: 24

Sequence:: Chromosome: X; NC_003284.9 (3171420..3178701, complement)

Chromosome X - NC_003284.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Study indicates kinesin KLP-4 as a novel regulator of anterograde GLR-1 glutamate receptors trafficking and reveals a cellular control mechanism by which receptor cargo is targeted for degradation in tje absence of its motor.
Title: The kinesin-3 family motor KLP-4 regulates anterograde trafficking of GLR-1 glutamate receptors in the ventral nerve cord of Caenorhabditis elegans.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F56E3.3 (e-PCR)
- UniSTS:311875

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IBA Inferred from Biological aspect of Ancestor more info
enables cytoskeletal motor activity	IEA Inferred from Electronic Annotation more info
enables microtubule binding	IBA Inferred from Biological aspect of Ancestor more info
enables microtubule binding	IEA Inferred from Electronic Annotation more info
enables microtubule motor activity	IBA Inferred from Biological aspect of Ancestor more info
enables microtubule motor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in microtubule-based movement	IEA Inferred from Electronic Annotation more info
involved_in vesicle transport along microtubule	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in axon	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasmic microtubule	IDA Inferred from Direct Assay more info	PubMed
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
part_of kinesin complex	IBA Inferred from Biological aspect of Ancestor more info
is_active_in microtubule	IBA Inferred from Biological aspect of Ancestor more info
located_in microtubule	IEA Inferred from Electronic Annotation more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: Kinesin motor domain-containing protein

NP_001359864.1

Confirmed by transcript evidence

NP_001379674.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003284.9 Reference assembly

Range

3171420..3178701 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001373257.3 → NP_001359864.1 Kinesin motor domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

Q8MQ20

Conserved Domains (5) summary

smart00240
Location:496 → 545

FHA; Forkhead associated domain

cd01365
Location:10 → 354

KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins

pfam12423
Location:776 → 840

KIF1B; Kinesin protein 1B

pfam12473
Location:1239 → 1293

DUF3694; Kinesin protein

pfam16183
Location:351 → 463

Kinesin_assoc; Kinesin-associated
NM_001392742.1 → NP_001379674.1 Kinesin motor domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

Q20888

Conserved Domains (5) summary

smart00240
Location:496 → 545

FHA; Forkhead associated domain

cd01365
Location:10 → 354

KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins

pfam12423
Location:776 → 840

KIF1B; Kinesin protein 1B

pfam12473
Location:1239 → 1293

DUF3694; Kinesin protein

pfam16183
Location:351 → 463

Kinesin_assoc; Kinesin-associated