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glt-1 Excitatory amino acid transporter [ Caenorhabditis elegans ]

Gene ID: 180641, updated on 2-Nov-2024

Summary

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Official Symbol
glt-1
Official Full Name
Excitatory amino acid transporter
Primary source
WormBase:WBGene00001620
Locus tag
CELE_C12D12.2
See related
AllianceGenome:WB:WBGene00001620
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables L-glutamate transmembrane transporter activity. Predicted to be involved in L-glutamate transmembrane transport. Located in cell projection. Is expressed in body wall musculature; cephalic sheath cell; hypodermis; and muscle cell. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 41. Orthologous to human SLC1A2 (solute carrier family 1 member 2). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See glt-1 in Genome Data Viewer
Location:
chromosome: X
Exon count:
9
Sequence:
Chromosome: X; NC_003284.9 (3496026..3499169)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene BI1-like protein Neighboring gene IgGFc_binding domain-containing protein Neighboring gene HMG box domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Structure and activity of a new form of the glutamate transporter of the nematode Caenorhabditis elegans. Kawano T, et al. Biosci Biotechnol Biochem, 1997 May. PMID 9178573
  2. Cloning and characterization of cDNAs encoding putative glutamate transporters from Caenorhabditis elegans and Onchocerca volvulus. Radice AD, et al. Mol Biochem Parasitol, 1996 Sep. PMID 8885221
  3. Glutamate spillover in C. elegans triggers repetitive behavior through presynaptic activation of MGL-2/mGluR5. Katz M, et al. Nat Commun, 2019 Apr 23. PMID 31015396, Free PMC Article
  4. Glial Expression of the Caenorhabditis elegans Gene swip-10 Supports Glutamate Dependent Control of Extrasynaptic Dopamine Signaling. Hardaway JA, et al. J Neurosci, 2015 Jun 24. PMID 26109664, Free PMC Article
  5. Guanosine Prevents against Glutamatergic Excitotoxicity in C. elegans. da Silveira TL, et al. Neuroscience, 2019 Aug 21. PMID 31306683

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables L-glutamate transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables L-glutamate transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables glutamate:sodium symporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables neutral L-amino acid transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables symporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in L-alpha-amino acid transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in L-glutamate transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in neutral amino acid transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cell projection IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 

General protein information

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Preferred Names
Excitatory amino acid transporter
NP_001024393.1
  • Confirmed by transcript evidence
NP_001024394.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    3496026..3499169
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001029222.4 → NP_001024393.1  Excitatory amino acid transporter [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001024393.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P90798, Q10901, Q17920
    Conserved Domains (1) summary
    pfam00375
    Location:21 → 458
    SDF; Sodium:dicarboxylate symporter family

  2. NM_001029223.6 → NP_001024394.1  Excitatory amino acid transporter [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001024394.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q10901
    Conserved Domains (1) summary
    pfam00375
    Location:10 → 447
    SDF; Sodium:dicarboxylate symporter family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q10901.2

Gene LinkOut

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