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rgs-7 C2 domain-containing protein;RGS domain-containing protein;Regulator of G-protein signaling rgs-7 [ Caenorhabditis elegans ]

Gene ID: 180645, updated on 2-Nov-2024

Summary

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Official Symbol
rgs-7
Official Full Name
C2 domain-containing protein;RGS domain-containing protein;Regulator of G-protein signaling rgs-7
Primary source
WormBase:WBGene00004350
Locus tag
CELE_F56B6.2
See related
AllianceGenome:WB:WBGene00004350
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables GTPase activator activity. Predicted to be involved in negative regulation of signal transduction. Located in cell cortex. Is expressed in head neurons. Orthologous to several human genes including RGS1 (regulator of G protein signaling 1); RGS13 (regulator of G protein signaling 13); and RGS18 (regulator of G protein signaling 18). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See rgs-7 in Genome Data Viewer
Location:
chromosome: X
Exon count:
18
Sequence:
Chromosome: X; NC_003284.9 (3542542..3557783)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene G-protein coupled receptors family 1 profile domain-containing protein Neighboring gene CC domain-containing protein Neighboring gene Glycogenin-1 Neighboring gene Vitellogenin-4 Neighboring gene ncRNA Neighboring gene Vitellogenin-3 Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A conserved protein interaction interface on the type 5 G protein beta subunit controls proteolytic stability and activity of R7 family regulator of G protein signaling proteins. Porter MY, et al. J Biol Chem, 2010 Dec 24. PMID 20959458, Free PMC Article
  2. Characterization of a novel C. elegans RGS protein with a C2 domain: evidence for direct association between C2 domain and Galphaq subunit. Sato M, et al. Life Sci, 2003 Jul 4. PMID 12798417
  3. RGS-7 completes a receptor-independent heterotrimeric G protein cycle to asymmetrically regulate mitotic spindle positioning in C. elegans. Hess HA, et al. Cell, 2004 Oct 15. PMID 15479638
  4. A point mutation to Galphai selectively blocks GoLoco motif binding: direct evidence for Galpha.GoLoco complexes in mitotic spindle dynamics. Willard FS, et al. J Biol Chem, 2008 Dec 26. PMID 18984596, Free PMC Article
  5. Heterotrimeric G proteins: new tricks for an old dog. Hampoelz B, et al. Cell, 2004 Nov 12. PMID 15537535

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. conserved protein interaction interface on the type 5 G protein beta subunit controls proteolytic stability and activity of R7 family regulator of G protein signaling proteins.
    Title: A conserved protein interaction interface on the type 5 G protein beta subunit controls proteolytic stability and activity of R7 family regulator of G protein signaling proteins.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables GTPase activator activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cell cortex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
C2 domain-containing protein;RGS domain-containing protein;Regulator of G-protein signaling rgs-7
NP_001024714.1
  • Confirmed by transcript evidence
NP_001024715.1
  • Confirmed by transcript evidence
NP_001123153.1
  • Confirmed by transcript evidence
NP_001123154.1
  • Confirmed by transcript evidence
NP_001360776.1
  • Confirmed by transcript evidence
NP_001360777.1
  • Confirmed by transcript evidence
NP_001360778.1
  • Confirmed by transcript evidence
NP_001361946.1
  • Confirmed by transcript evidence
NP_508610.3
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    3542542..3557783
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_076209.7 → NP_508610.3  Regulator of G-protein signaling rgs-7 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_508610.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8WQC0, Q95Q48, Q95Q49
    Conserved Domains (2) summary
    smart00239
    Location:308 → 425
    C2; Protein kinase C conserved region 2 (CalB)
    pfam00615
    Location:682 → 787
    RGS; Regulator of G protein signaling domain

  2. NM_001373260.4 → NP_001360776.1  C2 domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A4V0IKM4
    Conserved Domains (2) summary
    smart00239
    Location:310 → 427
    C2; Protein kinase C conserved region 2 (CalB)
    pfam00615
    Location:687 → 792
    RGS; Regulator of G protein signaling domain

  3. NM_001373261.4 → NP_001360777.1  C2 domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A4V0IJG9
    Conserved Domains (2) summary
    smart00239
    Location:310 → 427
    C2; Protein kinase C conserved region 2 (CalB)
    pfam00615
    Location:684 → 789
    RGS; Regulator of G protein signaling domain

  4. NM_001373262.3 → NP_001360778.1  C2 domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A4V0ILX5
    Conserved Domains (2) summary
    smart00239
    Location:308 → 425
    C2; Protein kinase C conserved region 2 (CalB)
    pfam00615
    Location:685 → 790
    RGS; Regulator of G protein signaling domain

  5. NM_001029543.5 → NP_001024714.1  Regulator of G-protein signaling rgs-7 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001024714.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8WQC0
    Conserved Domains (2) summary
    smart00239
    Location:271 → 388
    C2; Protein kinase C conserved region 2 (CalB)
    pfam00615
    Location:645 → 750
    RGS; Regulator of G protein signaling domain

  6. NM_001029544.6 → NP_001024715.1  Regulator of G-protein signaling rgs-7 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001024715.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8WQC0
    Conserved Domains (1) summary
    pfam00615
    Location:287 → 392
    RGS; Regulator of G protein signaling domain

  7. NM_001374994.1 → NP_001361946.1  RGS domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q1W0R0
    Conserved Domains (1) summary
    pfam00615
    Location:187 → 292
    RGS; Regulator of G protein signaling domain

  8. NM_001129681.4 → NP_001123153.1  RGS domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001123153.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    H2KYQ7
    Conserved Domains (1) summary
    pfam00615
    Location:103 → 208
    RGS; Regulator of G protein signaling domain

  9. NM_001129682.5 → NP_001123154.1  RGS domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001123154.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    H2KYQ8
    Conserved Domains (1) summary
    pfam00615
    Location:78 → 183
    RGS; Regulator of G protein signaling domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8WQC0.2

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