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ptp-4A2 TYR_PHOSPHATASE_2 domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 180677, updated on 2-Nov-2024

Summary

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Official Symbol
ptp-4A2
Official Full Name
TYR_PHOSPHATASE_2 domain-containing protein
Primary source
WormBase:WBGene00004184
Locus tag
CELE_T19D2.2
See related
AllianceGenome:WB:WBGene00004184
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable protein tyrosine phosphatase activity. Predicted to be involved in protein dephosphorylation. Predicted to be active in cytoplasm and nucleus. Orthologous to several human genes including PTP4A2 (protein tyrosine phosphatase 4A2). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See ptp-4A2 in Genome Data Viewer
Location:
chromosome: X
Exon count:
5
Sequence:
Chromosome: X; NC_003284.9 (3940130..3943313, complement)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Peptidase M12B domain-containing protein Neighboring gene Uncharacterized protein Neighboring gene Uncharacterized protein Neighboring gene ncRNA Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. RNAi mediated gene knockdown and transgenesis by microinjection in the necromenic Nematode Pristionchus pacificus. Cinkornpumin JK, et al. J Vis Exp, 2011 Oct 16. PMID 22025167, Free PMC Article
  2. Knockdown of phosphatases of regenerating liver-1 prolongs the lifespan of Caenorhabditis elegans via activating DAF-16/FOXO. Yu Y, et al. FASEB J, 2023 Apr. PMID 36906287
  3. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
  4. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
  5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables protein tyrosine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein tyrosine phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in protein dephosphorylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
TYR_PHOSPHATASE_2 domain-containing protein
NP_001379679.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    3940130..3943313 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001392757.1 → NP_001379679.1  TYR_PHOSPHATASE_2 domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5EG43
    Conserved Domains (1) summary
    cd14500
    Location:22 → 173
    PTP-IVa; protein tyrosine phosphatase type IVA family
Nucleotide Protein
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