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hrg-1 Heme transporter hrg-1 [ Caenorhabditis elegans ]

Gene ID: 180684, updated on 2-Nov-2024

Summary

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Official Symbol
hrg-1
Official Full Name
Heme transporter hrg-1
Primary source
WormBase:WBGene00019830
Locus tag
CELE_R02E12.6
See related
AllianceGenome:WB:WBGene00019830
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables heme binding activity and heme transmembrane transporter activity. Involved in heme transport. Located in endosome membrane and lysosomal membrane. Is expressed in intestine. Orthologous to human SLC48A1 (solute carrier family 48 member 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See hrg-1 in Genome Data Viewer
Location:
chromosome: X
Exon count:
4
Sequence:
Chromosome: X; NC_003284.9 (4008058..4016221, complement)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene RING-type domain-containing protein Neighboring gene Tektin Neighboring gene ncRNA Neighboring gene uncharacterized protein Neighboring gene AcetylCholine Receptor Neighboring gene Uncharacterized protein Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Haem transporter HRG-1 is essential in the barber's pole worm and an intervention target candidate. Yang Y, et al. PLoS Pathog, 2023 Jan. PMID 36716341, Free PMC Article
  2. Heme acquisition in the parasitic filarial nematode Brugia malayi. Luck AN, et al. FASEB J, 2016 Oct. PMID 27363426, Free PMC Article
  3. Heme metabolism and erythropoiesis. Chung J, et al. Curr Opin Hematol, 2012 May. PMID 22406824, Free PMC Article
  4. Topologically conserved residues direct heme transport in HRG-1-related proteins. Yuan X, et al. J Biol Chem, 2012 Feb 10. PMID 22174408, Free PMC Article
  5. A novel heme-responsive element mediates transcriptional regulation in Caenorhabditis elegans. Sinclair J, et al. J Biol Chem, 2010 Dec 10. PMID 20938051, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. a model in which heme is translocated across membranes facilitated by conserved amino acids positioned on the exoplasmic, cytoplasmic, and transmembrane regions of HRG-1-related proteins.
    Title: Topologically conserved residues direct heme transport in HRG-1-related proteins.
  2. hrg-1 is a heme-responsive element that mediates transcriptional regulation in Caenorhabditis elegans
    Title: A novel heme-responsive element mediates transcriptional regulation in Caenorhabditis elegans.
  3. identification of HRG-1 protein in C. elegans; these proteins are essential for haem homeostasis and normal development
    Title: Haem homeostasis is regulated by the conserved and concerted functions of HRG-1 proteins.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables heme binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables heme binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables heme transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables heme transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables heme transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in heme transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in heme transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in heme transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in endosome IEA
Inferred from Electronic Annotation
more info
  
located_in endosome membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endosome membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in lysosomal membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in lysosomal membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in lysosomal membrane IEA
Inferred from Electronic Annotation
more info
  
located_in lysosome IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Heme transporter hrg-1
NP_001370439.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    4008058..4016221 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001383555.2 → NP_001370439.1  Heme transporter hrg-1 [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q21642
    Conserved Domains (1) summary
    pfam16954
    Location:107 → 161
    HRG; Haem-transporter, endosomal/lysosomal, haem-responsive gene
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q21642.2

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