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mrp-6 Multidrug resistance-associated protein lethal(2)03659 [ Caenorhabditis elegans ]

Gene ID: 180691, updated on 2-Nov-2024

Summary

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Official Symbol
mrp-6
Official Full Name
Multidrug resistance-associated protein lethal(2)03659
Primary source
WormBase:WBGene00003412
Locus tag
CELE_F20B6.3
See related
AllianceGenome:WB:WBGene00003412
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable ATPase-coupled transmembrane transporter activity. Predicted to be involved in transmembrane transport. Predicted to be active in membrane. Is expressed in hypodermis; intestine; and nervous system. Orthologous to human ABCC4 (ATP binding cassette subfamily C member 4 (PEL blood group)). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See mrp-6 in Genome Data Viewer
Location:
chromosome: X
Exon count:
18
Sequence:
Chromosome: X; NC_003284.9 (4177989..4186756, complement)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene MD-2-related lipid-recognition domain-containing protein Neighboring gene ncRNA Neighboring gene V-type proton ATPase subunit B 1 Neighboring gene Envelope glycoprotein UL132

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The gut efflux pump MRP-1 exports oxidized glutathione as a danger signal that stimulates behavioral immunity and aversive learning. Lalsiamthara J, et al. Commun Biol, 2022 May 5. PMID 35513700, Free PMC Article
  2. The role of several ABC transporter genes in ivermectin resistance in Caenorhabditis elegans. Yan R, et al. Vet Parasitol, 2012 Dec 21. PMID 22840641
  3. An RNAi screen identifies genes that regulate GABA synapses. Vashlishan AB, et al. Neuron, 2008 May 8. PMID 18466746
  4. ATP-binding cassette transporters are required for efficient RNA interference in Caenorhabditis elegans. Sundaram P, et al. Mol Biol Cell, 2006 Aug. PMID 16723499, Free PMC Article
  5. Caenorhabditis elegans ABCRNAi transporters interact genetically with rde-2 and mut-7. Sundaram P, et al. Genetics, 2008 Feb. PMID 18245353, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ABC-type transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables ATPase-coupled transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Multidrug resistance-associated protein lethal(2)03659
NP_001362008.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    4177989..4186756 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001375011.2 → NP_001362008.1  Multidrug resistance-associated protein lethal(2)03659 [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q19625
    Conserved Domains (1) summary
    TIGR00957
    Location:126 → 1389
    MRP_assoc_pro; multi drug resistance-associated protein (MRP)
Nucleotide Protein
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