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hpk-1 Homeodomain-interacting protein kinase 1 [ Caenorhabditis elegans ]

Gene ID: 180695, updated on 2-Nov-2024

Summary

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Official Symbol
hpk-1
Official Full Name
Homeodomain-interacting protein kinase 1
Primary source
WormBase:WBGene00001994
Locus tag
CELE_F20B6.8
See related
AllianceGenome:WB:WBGene00001994
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable protein serine/threonine kinase activity and protein tyrosine kinase activity. Involved in several processes, including autophagosome assembly; determination of adult lifespan; and response to heat. Located in nucleus. Is expressed in several structures, including gonad; hypodermal cell; intestine; neurons; and pharyngeal cell. Used to study Parkinson's disease. Orthologous to several human genes including HIPK1 (homeodomain interacting protein kinase 1); HIPK2 (homeodomain interacting protein kinase 2); and HIPK3 (homeodomain interacting protein kinase 3). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See hpk-1 in Genome Data Viewer
Location:
chromosome: X
Exon count:
9
Sequence:
Chromosome: X; NC_003284.9 (4210571..4217290, complement)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Tyrosine-protein phosphatase domain-containing protein Neighboring gene Uncharacterized protein Neighboring gene pseudo Neighboring gene Uncharacterized protein Neighboring gene Uncharacterized protein Neighboring gene ncRNA Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Homeodomain interacting protein kinase (HPK-1) is required in the soma for robust germline proliferation in C. elegans. Berber S, et al. Dev Dyn, 2013 Nov. PMID 23904186
  2. Homeodomain-Interacting Protein Kinase (HPK-1) regulates stress responses and ageing in C. elegans. Berber S, et al. Sci Rep, 2016 Jan 21. PMID 26791749, Free PMC Article
  3. Characterization of Caenorhabditis elegans homologs of the Down syndrome candidate gene DYRK1A. Raich WB, et al. Genetics, 2003 Feb. PMID 12618396, Free PMC Article
  4. Homeodomain-interacting protein kinase maintains neuronal homeostasis during normal Caenorhabditis elegans aging and systemically regulates longevity from serotonergic and GABAergic neurons. Lazaro-Pena MI, et al. Elife, 2023 Jun 20. PMID 37338980, Free PMC Article
  5. The homeodomain-interacting protein kinase HPK-1 preserves protein homeostasis and longevity through master regulatory control of the HSF-1 chaperone network and TORC1-restricted autophagy in Caenorhabditis elegans. Das R, et al. PLoS Genet, 2017 Oct. PMID 29036198, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. These functions of HPK-1/HSF-1 undergo rapid down-regulation once animals reach reproductive maturity. We show that HPK-1 fortifies proteostasis and extends longevity by an additional independent mechanism: induction of autophagy.
    Title: The homeodomain-interacting protein kinase HPK-1 preserves protein homeostasis and longevity through master regulatory control of the HSF-1 chaperone network and TORC1-restricted autophagy in Caenorhabditis elegans.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in autophagosome assembly IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in autophagy IEA
Inferred from Electronic Annotation
more info
  
involved_in determination of adult lifespan IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in response to heat IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to oxidative stress IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Homeodomain-interacting protein kinase 1
NP_741761.1
  • Partially confirmed by transcript evidence
NP_741762.1
  • Confirmed by transcript evidence
NP_741763.1
  • Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    4210571..4217290 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_171663.4 → NP_741762.1  Homeodomain-interacting protein kinase 1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_741762.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8MQ70
    Conserved Domains (2) summary
    smart00220
    Location:122 → 458
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:122 → 458
    PKc_like; Protein Kinases, catalytic domain

  2. NM_171662.10 → NP_741761.1  Homeodomain-interacting protein kinase 1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_741761.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q19632, Q8MQ69, Q8MQ70
    Conserved Domains (2) summary
    smart00220
    Location:147 → 483
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:147 → 483
    PKc_like; Protein Kinases, catalytic domain

  3. NM_171664.7 → NP_741763.1  Homeodomain-interacting protein kinase 1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_741763.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8MQ70
    Conserved Domains (2) summary
    smart00220
    Location:41 → 377
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:41 → 377
    PKc_like; Protein Kinases, catalytic domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8MQ70.1

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