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cst-1 Serine/threonine-protein kinase cst-1 37kDa subunit [ Caenorhabditis elegans ]

Gene ID: 180708, updated on 2-Nov-2024

Summary

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Official Symbol
cst-1
Official Full Name
Serine/threonine-protein kinase cst-1 37kDa subunit
Primary source
WormBase:WBGene00017472
Locus tag
CELE_F14H12.4
See related
AllianceGenome:WB:WBGene00017472
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable protein serine/threonine kinase activity. Involved in determination of adult lifespan and muscle cell development. Predicted to be active in cytoplasm. Is expressed in hypodermis; sensory neurons; terminal bulb; and vulva. Human ortholog(s) of this gene implicated in primary immunodeficiency disease. Orthologous to several human genes including STK3 (serine/threonine kinase 3). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See cst-1 in Genome Data Viewer
Location:
chromosome: X
Exon count:
12
Sequence:
Chromosome: X; NC_003284.9 (4339632..4343706)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Thrombospondin type 1 domain protein Neighboring gene Uncharacterized protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Hippo kinases maintain polarity during directional cell migration in Caenorhabditis elegans. Feng G, et al. EMBO J, 2017 Feb 1. PMID 28011581, Free PMC Article
  2. Characterization of RSF-1, the Caenorhabditis elegans homolog of the Ras-association domain family protein 1. Iwasa H, et al. Exp Cell Res, 2013 Feb 1. PMID 23103556
  3. Phosphorylation of LC3 by the Hippo kinases STK3/STK4 is essential for autophagy. Wilkinson DS, et al. Mol Cell, 2015 Jan 8. PMID 25544559, Free PMC Article
  4. MST, a physiological caspase substrate, highly sensitizes apoptosis both upstream and downstream of caspase activation. Lee KK, et al. J Biol Chem, 2001 Jun 1. PMID 11278283
  5. Yes-associated protein homolog, YAP-1, is involved in the thermotolerance and aging in the nematode Caenorhabditis elegans. Iwasa H, et al. Exp Cell Res, 2013 Apr 15. PMID 23396260

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
involved_in determination of adult lifespan IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in muscle cell development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in peptidyl-serine phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in positive regulation of apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in protein tetramerization IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of MAPK cascade IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Serine/threonine-protein kinase cst-1 37kDa subunit
NP_001024575.2
  • Confirmed by transcript evidence
NP_508743.4
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    4339632..4343706
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001029404.7 → NP_001024575.2  Serine/threonine-protein kinase cst-1 37kDa subunit [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001024575.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q2AAC7, Q9NB31
    Conserved Domains (3) summary
    cd06612
    Location:31 → 286
    STKc_MST1_2; Catalytic domain of the Serine/Threonine Kinases, Mammalian STe20-like protein kinase 1 and 2
    smart00220
    Location:35 → 286
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    pfam11629
    Location:446 → 493
    Mst1_SARAH; C terminal SARAH domain of Mst1

  2. NM_076342.6 → NP_508743.4  Serine/threonine-protein kinase cst-1 37kDa subunit [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_508743.4

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9NB31
    Conserved Domains (3) summary
    cd06612
    Location:31 → 286
    STKc_MST1_2; Catalytic domain of the Serine/Threonine Kinases, Mammalian STe20-like protein kinase 1 and 2
    smart00220
    Location:35 → 286
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    pfam11629
    Location:444 → 491
    Mst1_SARAH; C terminal SARAH domain of Mst1
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9NB31.1

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