ncr-1 NPC intracellular cholesterol transporter 1 homolog 1 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: ncr-1
Official Full Name: NPC intracellular cholesterol transporter 1 homolog 1
Primary source: WormBase:WBGene00003561
Locus tag: CELE_F02E8.6
See related: AllianceGenome:WB:WBGene00003561
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable cholesterol binding activity. Involved in several processes, including cholesterol homeostasis; positive regulation of growth rate; and regulation of egg-laying behavior. Predicted to be located in late endosome and lysosome. Predicted to be active in plasma membrane. Is expressed in several structures, including head neurons; hermaphrodite gonad; hypodermis; lumbar neurons; and pharynx. Used to study Niemann-Pick disease. Human ortholog(s) of this gene implicated in Niemann-Pick disease type C1. Orthologous to several human genes including NPC1 (NPC intracellular cholesterol transporter 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See ncr-1 in Genome Data Viewer

Location:: chromosome: X

Exon count:: 18

Sequence:: Chromosome: X; NC_003284.9 (4472244..4488857, complement)

Chromosome X - NC_003284.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The small GTPase RAB-18 is involved in regulating development/diapause by recruiting the intestinal cholesterol transporter NCR-1 onto the apical side in Caenorhabditis elegans.
Title: The small GTPase RAB-18 is involved in regulating development/diapause by recruiting the intestinal cholesterol transporter NCR-1 onto the apical side in Caenorhabditis elegans.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F02E8.6 (e-PCR)
- UniSTS:309560

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables cholesterol binding	IBA Inferred from Biological aspect of Ancestor more info
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in cholesterol homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in cholesterol homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cholesterol transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dauer larval development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in intestinal cholesterol absorption	IBA Inferred from Biological aspect of Ancestor more info
involved_in lipid transport	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of growth rate	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of egg-laying behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sterol transport	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in late endosome	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in lysosome	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: NPC intracellular cholesterol transporter 1 homolog 1

NP_508771.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003284.9 Reference assembly

Range

4472244..4488857 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_076370.5 → NP_508771.1 NPC intracellular cholesterol transporter 1 homolog 1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_508771.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q19127

Conserved Domains (3) summary

TIGR00917
Location:22 → 1284

2A060601; Niemann-Pick C type protein family

pfam16414
Location:22 → 251

NPC1_N; Niemann-Pick C1 N terminus

cl21543
Location:660 → 814

MMPL; MMPL family