U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

dgk-2 DAGKc domain-containing protein;Diacylglycerol kinase [ Caenorhabditis elegans ]

Gene ID: 180720, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
dgk-2
Official Full Name
DAGKc domain-containing protein;Diacylglycerol kinase
Primary source
WormBase:WBGene00000959
Locus tag
CELE_F46H6.2
See related
AllianceGenome:WB:WBGene00000959
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable ATP-dependent diacylglycerol kinase activity. Predicted to be involved in glycerolipid metabolic process and intracellular signal transduction. Predicted to be active in membrane. Human ortholog(s) of this gene implicated in nephrotic syndrome type 7. Orthologous to human DGKE (diacylglycerol kinase epsilon). [provided by Alliance of Genome Resources, Nov 2024]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See dgk-2 in Genome Data Viewer
Location:
chromosome: X
Exon count:
12
Sequence:
Chromosome: X; NC_003284.9 (4494919..4504388, complement)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Uncharacterized protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. PKC-2 phosphorylation of UNC-18 Ser322 in AFD neurons regulates temperature dependency of locomotion. Edwards MR, et al. J Neurosci, 2012 May 16. PMID 22593072, Free PMC Article
  2. Goalpha regulates olfactory adaptation by antagonizing Gqalpha-DAG signaling in Caenorhabditis elegans. Matsuki M, et al. Proc Natl Acad Sci U S A, 2006 Jan 24. PMID 16418272, Free PMC Article
  3. Oscillatory Ca2+ signaling in the isolated Caenorhabditis elegans intestine: role of the inositol-1,4,5-trisphosphate receptor and phospholipases C beta and gamma. Espelt MV, et al. J Gen Physiol, 2005 Oct. PMID 16186564, Free PMC Article
  4. Nuclear receptor binding protein 1 regulates intestinal progenitor cell homeostasis and tumour formation. Wilson CH, et al. EMBO J, 2012 May 30. PMID 22510880, Free PMC Article
  5. Inositol monophosphatase regulates localization of synaptic components and behavior in the mature nervous system of C. elegans. Tanizawa Y, et al. Genes Dev, 2006 Dec 1. PMID 17158747, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP-dependent diacylglycerol kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ATP-dependent diacylglycerol kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in glycerolipid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
DAGKc domain-containing protein;Diacylglycerol kinase
NP_001024679.1
  • Confirmed by transcript evidence
NP_001024680.1
  • Confirmed by transcript evidence
NP_001379634.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    4494919..4504388 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001029508.6 → NP_001024679.1  Diacylglycerol kinase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001024679.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    H2KYI9
    Conserved Domains (3) summary
    cd00029
    Location:110 → 159
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    pfam00781
    Location:203 → 325
    DAGK_cat; Diacylglycerol kinase catalytic domain
    cl02440
    Location:350 → 503
    DAGK_acc; Diacylglycerol kinase accessory domain

  2. NM_001392762.1 → NP_001379634.1  Diacylglycerol kinase [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7Z299
    Conserved Domains (2) summary
    pfam00781
    Location:18 → 140
    DAGK_cat; Diacylglycerol kinase catalytic domain
    cl02440
    Location:165 → 318
    DAGK_acc; Diacylglycerol kinase accessory domain

  3. NM_001029509.6 → NP_001024680.1  DAGKc domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001024680.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7Z2A0
    Conserved Domains (1) summary
    pfam00781
    Location:18 → 126
    DAGK_cat; Diacylglycerol kinase catalytic domain
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.