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mls-2 Homeobox protein mls-2 [ Caenorhabditis elegans ]

Gene ID: 180751, updated on 2-Nov-2024

Summary

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Official Symbol
mls-2
Official Full Name
Homeobox protein mls-2
Primary source
WormBase:WBGene00003377
Locus tag
CELE_C39E6.4
See related
AllianceGenome:WB:WBGene00003377
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including establishment of mitotic spindle orientation; neuron differentiation involved in amphid sensory organ development; and positive regulation of glial cell differentiation. Located in nucleus. Is expressed in several structures, including AB lineage cell; ABplpa; AWC-ON; head; and somatic nervous system. Human ortholog(s) of this gene implicated in oculoauricular syndrome. Orthologous to several human genes including HMX1 (H6 family homeobox 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See mls-2 in Genome Data Viewer
Location:
chromosome: X
Exon count:
6
Sequence:
Chromosome: X; NC_003284.9 (4758804..4761640, complement)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. mNG-tagged mls-2 knock-in alleles in C. elegans. Xiong R, et al. MicroPubl Biol, 2022. PMID 35224463, Free PMC Article
  2. The Nkx5/HMX homeodomain protein MLS-2 is required for proper tube cell shape in the C. elegans excretory system. Abdus-Saboor I, et al. Dev Biol, 2012 Jun 15. PMID 22537498, Free PMC Article
  3. Synergistic roles of homeodomain proteins UNC-62 homothorax and MLS-2 HMX/NKX in the specification of olfactory neurons in Caenorhabditis elegans. Hsieh YW, et al. Genetics, 2021 Oct 2. PMID 34849889, Free PMC Article
  4. The HMX/NKX homeodomain protein MLS-2 specifies the identity of the AWC sensory neuron type via regulation of the ceh-36 Otx gene in C. elegans. Kim K, et al. Development, 2010 Mar. PMID 20150279, Free PMC Article
  5. UNC-42 function is required for the ectopic expression of ASH markers in mls-2 mutant animals. Wood J, et al. MicroPubl Biol, 2019 Jun 12. PMID 32550438, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Synergistic roles of homeodomain proteins UNC-62 homothorax and MLS-2 HMX/NKX in the specification of olfactory neurons in Caenorhabditis elegans.
    Title: Synergistic roles of homeodomain proteins UNC-62 homothorax and MLS-2 HMX/NKX in the specification of olfactory neurons in Caenorhabditis elegans.
  2. MLS-2 is a regulator of cell shape in the duct cell during morphogenesis
    Title: The Nkx5/HMX homeodomain protein MLS-2 is required for proper tube cell shape in the C. elegans excretory system.
  3. MLS-2 specifies the identity of the AWC sensory neuron type via regulation of the ceh-36 Otx gene.
    Title: The HMX/NKX homeodomain protein MLS-2 specifies the identity of the AWC sensory neuron type via regulation of the ceh-36 Otx gene in C. elegans.
  4. demonstrate ventral- and dorsal-restricted roles for the mls-2/Nkx/Hmx and vab-3/Pax6/Pax7 genes, respectively, in CEPsh glia differentiation and expression of the genes hlh-17/Olig and ptr-10/Patched-related
    Title: mls-2 and vab-3 Control glia development, hlh-17/Olig expression and glia-dependent neurite extension in C. elegans.
  5. mls-2 might be a direct target of CEH-20 in the M lineage and the regulation of CEH-20 on mls-2 is likely Hox-independent
    Title: Mesodermal expression of the C. elegans HMX homolog mls-2 requires the PBC homolog CEH-20.
  6. The HMX homeodomain protein MLS-2 regulates cleavage orientation, cell proliferation and cell fate specification in the C. elegans postembryonic mesoderm.
    Title: The HMX homeodomain protein MLS-2 regulates cleavage orientation, cell proliferation and cell fate specification in the C. elegans postembryonic mesoderm.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in establishment of mitotic spindle orientation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nematode larval development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in neuron differentiation involved in amphid sensory organ development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of glial cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of mesodermal cell fate specification IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Homeobox protein mls-2
NP_508815.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    4758804..4761640 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_076414.7 → NP_508815.2  Homeobox protein mls-2 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_508815.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q18533
    Conserved Domains (1) summary
    pfam00046
    Location:204 → 258
    Homeobox; Homeobox domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q18533.2

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