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R08E3.3 CCDC22 N-terminal domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 180757, updated on 2-Nov-2024

Summary

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Official Symbol
R08E3.3
Official Full Name
CCDC22 N-terminal domain-containing protein
Primary source
WormBase:WBGene00019959
Locus tag
CELE_R08E3.3
See related
AllianceGenome:WB:WBGene00019959
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable cullin family protein binding activity. Predicted to be involved in positive regulation of ubiquitin-dependent protein catabolic process. Is expressed in anterior gonad arm. Human ortholog(s) of this gene implicated in Ritscher-Schinzel syndrome 2. Orthologous to human CCDC22 (coiled-coil domain containing 22). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See R08E3.3 in Genome Data Viewer
Location:
chromosome: X
Exon count:
12
Sequence:
Chromosome: X; NC_003284.9 (4818593..4821715)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene EGF-like domain-containing protein Neighboring gene GATOR2 complex protein MIO zinc-ribbon like domain-containing protein Neighboring gene Adducin-related protein 1;Class II aldolase/adducin N-terminal domain-containing protein Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Protein interaction mapping in C. elegans using proteins involved in vulval development. Walhout AJ, et al. Science, 2000 Jan 7. PMID 10615043
  2. C. elegans ORFeome version 1.1: experimental verification of the genome annotation and resource for proteome-scale protein expression. Reboul J, et al. Nat Genet, 2003 May. PMID 12679813
  3. A global analysis of genetic interactions in Caenorhabditis elegans. Byrne AB, et al. J Biol, 2007. PMID 17897480, Free PMC Article
  4. SH3 interactome conserves general function over specific form. Xin X, et al. Mol Syst Biol, 2013. PMID 23549480, Free PMC Article
  5. A map of the interactome network of the metazoan C. elegans. Li S, et al. Science, 2004 Jan 23. PMID 14704431, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables cullin family protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in positive regulation of ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
CCDC22 N-terminal domain-containing protein
NP_001024848.1
  • Confirmed by transcript evidence
NP_001024849.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    4818593..4821715
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001029678.7 → NP_001024849.1  CCDC22 N-terminal domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001024849.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7JP60
    Conserved Domains (3) summary
    pfam05667
    Location:1 → 420
    DUF812; Protein of unknown function (DUF812)
    pfam07889
    Location:284 → 350
    DUF1664; Protein of unknown function (DUF1664)
    pfam12010
    Location:259 → 297
    DUF3502; Domain of unknown function (DUF3502)

  2. NM_001029677.4 → NP_001024848.1  CCDC22 N-terminal domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001024848.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    H2L007
    Conserved Domains (3) summary
    pfam05667
    Location:1 → 420
    DUF812; Protein of unknown function (DUF812)
    pfam07889
    Location:284 → 350
    DUF1664; Protein of unknown function (DUF1664)
    pfam12010
    Location:259 → 297
    DUF3502; Domain of unknown function (DUF3502)
Nucleotide Protein
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