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act-4 Actin;Actin-4 [ Caenorhabditis elegans ]

Gene ID: 180767, updated on 2-Nov-2024

Summary

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Official Symbol
act-4
Official Full Name
Actin;Actin-4
Primary source
WormBase:WBGene00000066
Locus tag
CELE_M03F4.2
See related
AllianceGenome:WB:WBGene00000066
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to be a structural constituent of cytoskeleton. Predicted to be involved in actin cytoskeleton organization and mitotic cytokinesis. Located in striated muscle thin filament. Is expressed in body wall muscle quadrant; body wall musculature; gonad; pharynx; and vulval muscle. Human ortholog(s) of this gene implicated in Baraitser-Winter syndrome 1; Baraitser-Winter syndrome 2; autosomal dominant nonsyndromic deafness 20; and thrombocytopenia. Orthologous to several human genes including ACTB (actin beta). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See act-4 in Genome Data Viewer
Location:
chromosome: X
Exon count:
4
Sequence:
Chromosome: X; NC_003284.9 (4960621..4964413)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene G-protein coupled receptors family 1 profile domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Uncharacterized protein Neighboring gene EB domain-containing protein Neighboring gene EF-hand domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A novel actin barbed-end-capping activity in EPS-8 regulates apical morphogenesis in intestinal cells of Caenorhabditis elegans. Croce A, et al. Nat Cell Biol, 2004 Dec. PMID 15558032
  2. Mutations in Caenorhabditis elegans actin, which are equivalent to human cardiomyopathy mutations, cause abnormal actin aggregation in nematode striated muscle. Hayashi Y, et al. F1000Res, 2019. PMID 30984387, Free PMC Article
  3. Early C. elegans embryos are transcriptionally active. Schauer IE, et al. Development, 1990 Dec. PMID 2100265
  4. A Caenorhabditis elegans act-4::lacZ fusion: use as a transformation marker and analysis of tissue-specific expression. Stone S, et al. Gene, 1993 Sep 15. PMID 8406009
  5. HIV-1 Nef-POTEE; A novel interaction modulates macrophage dissemination via mTORC2 signaling pathway. Vekariya U, et al. Life Sci, 2018 Dec 1. PMID 30391463

See all (64) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables structural constituent of cytoskeleton ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
involved_in actin cytoskeleton organization ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in mitotic cytokinesis IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in actin cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
located_in membrane raft HDA PubMed 
located_in striated muscle thin filament IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Actin;Actin-4
NP_001368079.1
  • Confirmed by transcript evidence
NP_508841.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    4960621..4964413
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_076440.8 → NP_508841.1  Actin-4 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_508841.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P10986, Q7YSY2
    Conserved Domains (1) summary
    PTZ00281
    Location:1 → 376
    PTZ00281; actin; Provisional

  2. NM_001380958.1 → NP_001368079.1  Actin [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q95ZL1
    Conserved Domains (1) summary
    cl17037
    Location:1 → 332
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P10986.2

Gene LinkOut

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