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tbc-7 Rab-GAP TBC domain-containing protein;TLDc domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 180784, updated on 2-Nov-2024

Summary

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Official Symbol
tbc-7
Official Full Name
Rab-GAP TBC domain-containing protein;TLDc domain-containing protein
Primary source
WormBase:WBGene00016292
Locus tag
CELE_C31H2.1
See related
AllianceGenome:WB:WBGene00016292
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to be located in cytoplasmic vesicle; membrane; and synapse. Is expressed in body wall musculature; head; intestine; and neurons. Human ortholog(s) of this gene implicated in DOORS syndrome; epilepsy (multiple); and nonsyndromic deafness (multiple). Orthologous to human TBC1D24 (TBC1 domain family member 24). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See tbc-7 in Genome Data Viewer
Location:
chromosome: X
Exon count:
20
Sequence:
Chromosome: X; NC_003284.9 (5134280..5146744)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Ovule protein Neighboring gene Nematode cuticle collagen N-terminal domain-containing protein Neighboring gene Uncharacterized protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Interferon-β-induced miR-1 alleviates toxic protein accumulation by controlling autophagy. Nehammer C, et al. Elife, 2019 Dec 4. PMID 31799933, Free PMC Article
  2. Germline stem cell integrity and quiescence are controlled by an AMPK-dependent neuronal trafficking pathway. Wong C, et al. PLoS Genet, 2023 Apr. PMID 37058536, Free PMC Article
  3. Gene activities that mediate increased life span of C. elegans insulin-like signaling mutants. Samuelson AV, et al. Genes Dev, 2007 Nov 15. PMID 18006689, Free PMC Article
  4. Adult-restricted gene knock-down reveals candidates that affect locomotive healthspan in C. elegans. Jushaj A, et al. Biogerontology, 2023 Apr. PMID 36662373
  5. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Component Evidence Code Pubs
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in synapse IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Rab-GAP TBC domain-containing protein;TLDc domain-containing protein
NP_001359912.1
  • Confirmed by transcript evidence
NP_001360675.1
  • Confirmed by transcript evidence
NP_741779.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    5134280..5146744
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001373289.3 → NP_001359912.1  Rab-GAP TBC domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    H2KZ54
    Conserved Domains (2) summary
    smart00164
    Location:196 → 409
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
    smart00584
    Location:498 → 672
    TLDc; domain in TBC and LysM domain containing proteins

  2. NM_171949.9 → NP_741779.1  Rab-GAP TBC domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_741779.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8MQB0
    Conserved Domains (2) summary
    smart00164
    Location:156 → 369
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
    smart00584
    Location:458 → 632
    TLDc; domain in TBC and LysM domain containing proteins

  3. NM_001373290.4 → NP_001360675.1  TLDc domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A4V0INB7
    Conserved Domains (2) summary
    smart00164
    Location:54 → 267
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
    smart00584
    Location:356 → 530
    TLDc; domain in TBC and LysM domain containing proteins
Nucleotide Protein
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