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rga-8 Rho-GAP domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 180799, updated on 2-Nov-2024

Summary

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Official Symbol
rga-8
Official Full Name
Rho-GAP domain-containing protein
Primary source
WormBase:WBGene00021324
Locus tag
CELE_Y34B4A.8
See related
AllianceGenome:WB:WBGene00021324
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable GTPase activator activity. Predicted to be involved in negative regulation of small GTPase mediated signal transduction; regulation of Rac protein signal transduction; and regulation of actin cytoskeleton organization. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in acquired immunodeficiency syndrome and skin melanoma. Orthologous to human ARHGAP17 (Rho GTPase activating protein 17); ARHGAP44 (Rho GTPase activating protein 44); and SH3BP1 (SH3 domain binding protein 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See rga-8 in Genome Data Viewer
Location:
chromosome: X
Exon count:
16
Sequence:
Chromosome: X; NC_003284.9 (5271710..5279774, complement)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Rap guanine nucleotide exchange factor 1;Ras-GEF domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Heparan-sulfate 6-O-sulfotransferase Neighboring gene UV radiation resistance-associated gene protein-like Neighboring gene tRNA Neighboring gene Vacuolar protein sorting-associated protein 41 homolog Neighboring gene Activator of G protein signaling;TPR_REGION domain-containing protein;Tetratricopeptide repeat protein 28 Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. RhoGAP RGA-8 supports morphogenesis in C. elegans by polarizing epithelia. Raduwan H, et al. Biol Open, 2020 Nov 26. PMID 33243762, Free PMC Article
  2. Actin and CDC-42 contribute to nuclear migration through constricted spaces in C. elegans. Ho J, et al. Development, 2023 Oct 1. PMID 37756590, Free PMC Article
  3. Dissection of the mammalian midbody proteome reveals conserved cytokinesis mechanisms. Skop AR, et al. Science, 2004 Jul 2. PMID 15166316, Free PMC Article
  4. SH3 interactome conserves general function over specific form. Xin X, et al. Mol Syst Biol, 2013. PMID 23549480, Free PMC Article
  5. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activator activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in negative regulation of small GTPase mediated signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of GTPase activity IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of Rac protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of actin cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Rho-GAP domain-containing protein
NP_001257018.1
  • Confirmed by transcript evidence
NP_001257019.1
  • Confirmed by transcript evidence
NP_001348821.1
  • Partially confirmed by transcript evidence
NP_001348822.1
  • Confirmed by transcript evidence
NP_001348823.1
  • Partially confirmed by transcript evidence
NP_001348824.1
  • Partially confirmed by transcript evidence
NP_001348825.1
  • Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    5271710..5279774 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001361808.3 → NP_001348822.1  Rho-GAP domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A2K5AU25
    Conserved Domains (2) summary
    cd04386
    Location:235 → 428
    RhoGAP_nadrin; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Nadrin-like proteins. Nadrin, also named Rich-1, has been shown to be involved in the regulation of Ca2+-dependent exocytosis in neurons and recently has been implicated in ...
    cl12013
    Location:58 → 246
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

  2. NM_001270089.4 → NP_001257018.1  Rho-GAP domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001257018.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    C5NU64
    Conserved Domains (2) summary
    cd04386
    Location:235 → 428
    RhoGAP_nadrin; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Nadrin-like proteins. Nadrin, also named Rich-1, has been shown to be involved in the regulation of Ca2+-dependent exocytosis in neurons and recently has been implicated in ...
    cl12013
    Location:58 → 246
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

  3. NM_001270090.4 → NP_001257019.1  Rho-GAP domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001257019.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    H2KZX8
    Conserved Domains (2) summary
    cd04386
    Location:235 → 428
    RhoGAP_nadrin; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Nadrin-like proteins. Nadrin, also named Rich-1, has been shown to be involved in the regulation of Ca2+-dependent exocytosis in neurons and recently has been implicated in ...
    cl12013
    Location:58 → 246
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

  4. NM_001361805.4 → NP_001348821.1  Rho-GAP domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A2K5AU23
    Conserved Domains (2) summary
    cd04386
    Location:286 → 479
    RhoGAP_nadrin; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Nadrin-like proteins. Nadrin, also named Rich-1, has been shown to be involved in the regulation of Ca2+-dependent exocytosis in neurons and recently has been implicated in ...
    cl12013
    Location:109 → 297
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

  5. NM_001361804.3 → NP_001348823.1  Rho-GAP domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A2K5AU29
    Conserved Domains (2) summary
    cd04386
    Location:286 → 479
    RhoGAP_nadrin; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Nadrin-like proteins. Nadrin, also named Rich-1, has been shown to be involved in the regulation of Ca2+-dependent exocytosis in neurons and recently has been implicated in ...
    cl12013
    Location:109 → 297
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

  6. NM_001361806.3 → NP_001348825.1  Rho-GAP domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A2K5AU32
    Conserved Domains (2) summary
    cd04386
    Location:243 → 436
    RhoGAP_nadrin; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Nadrin-like proteins. Nadrin, also named Rich-1, has been shown to be involved in the regulation of Ca2+-dependent exocytosis in neurons and recently has been implicated in ...
    cl12013
    Location:66 → 254
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

  7. NM_001361807.3 → NP_001348824.1  Rho-GAP domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A2K5AU28
    Conserved Domains (2) summary
    cd04386
    Location:243 → 436
    RhoGAP_nadrin; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Nadrin-like proteins. Nadrin, also named Rich-1, has been shown to be involved in the regulation of Ca2+-dependent exocytosis in neurons and recently has been implicated in ...
    cl12013
    Location:66 → 254
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
Nucleotide Protein
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