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rgs-6 Regulator of G-protein signaling rgs-6 [ Caenorhabditis elegans ]

Gene ID: 180840, updated on 2-Nov-2024

Summary

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Official Symbol
rgs-6
Official Full Name
Regulator of G-protein signaling rgs-6
Primary source
WormBase:WBGene00004349
Locus tag
CELE_C41G11.3
See related
AllianceGenome:WB:WBGene00004349
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable GTPase activator activity. Predicted to be involved in negative regulation of signal transduction. Human ortholog(s) of this gene implicated in nephrolithiasis. Orthologous to human RGS14 (regulator of G protein signaling 14). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See rgs-6 in Genome Data Viewer
Location:
chromosome: X
Exon count:
12
Sequence:
Chromosome: X; NC_003284.9 (5720440..5729023, complement)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene tRNA-Lys Neighboring gene ncRNA Neighboring gene Cytochrome P450 Neighboring gene Calcineurin-like phosphoesterase domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Multiple RGS proteins alter neural G protein signaling to allow C. elegans to rapidly change behavior when fed. Dong MQ, et al. Genes Dev, 2000 Aug 15. PMID 10950865, Free PMC Article
  2. Selection and validation of a set of reliable reference genes for quantitative sod gene expression analysis in C. elegans. Hoogewijs D, et al. BMC Mol Biol, 2008 Jan 22. PMID 18211699, Free PMC Article
  3. Adipocytes control food intake and weight regain via Vacuolar-type H(+) ATPase. Zapata RC, et al. Nat Commun, 2022 Aug 30. PMID 36042358, Free PMC Article
  4. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
  5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables GTPase activator activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in negative regulation of signal transduction IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Regulator of G-protein signaling rgs-6
NP_001294820.1
  • Confirmed by transcript evidence
NP_001294821.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    5720440..5729023 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001307892.4 → NP_001294821.1  Regulator of G-protein signaling rgs-6 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001294821.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A078BQK8
    Conserved Domains (1) summary
    smart00315
    Location:47 → 157
    RGS; Regulator of G protein signalling domain

  2. NM_001307891.4 → NP_001294820.1  Regulator of G-protein signaling rgs-6 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001294820.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A0A078BPH3, A0A078BQK8, Q18562, Q18563
    Conserved Domains (1) summary
    smart00315
    Location:47 → 157
    RGS; Regulator of G protein signalling domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q18563.4

Gene LinkOut

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