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mig-23 Nucleoside-diphosphatase mig-23 [ Caenorhabditis elegans ]

Gene ID: 180860, updated on 2-Nov-2024

Summary

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Official Symbol
mig-23
Official Full Name
Nucleoside-diphosphatase mig-23
Primary source
WormBase:WBGene00003254
Locus tag
CELE_R07E4.4
See related
AllianceGenome:WB:WBGene00003254
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables ADP phosphatase activity; GDP phosphatase activity; and UDP phosphatase activity. Involved in several processes, including gonad morphogenesis; positive regulation of protein glycosylation; and ribonucleoside diphosphate catabolic process. Located in cytoplasm. Is expressed in head; hypodermis; intestine; pharynx; and tail. Orthologous to human ENTPD4 (ectonucleoside triphosphate diphosphohydrolase 4) and ENTPD7 (ectonucleoside triphosphate diphosphohydrolase 7). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See mig-23 in Genome Data Viewer
Location:
chromosome: X
Exon count:
9
Sequence:
Chromosome: X; NC_003284.9 (5945813..5948869, complement)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene G-protein coupled receptors family 1 profile domain-containing protein Neighboring gene EB domain-containing protein Neighboring gene long-chain-fatty-acid--CoA ligase Neighboring gene VWFA domain-containing protein Neighboring gene Cytochrome b-c1 complex subunit 8

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Sweet control of cell migration, cytokinesis and organogenesis. Podbilewicz B. Nat Cell Biol, 2004 Jan. PMID 14704673
  2. ire-1-dependent transcriptional up-regulation of a lumenal uridine diphosphatase from Caenorhabditis elegans. Uccelletti D, et al. J Biol Chem, 2004 Jun 25. PMID 15102851
  3. An NDPase links ADAM protease glycosylation with organ morphogenesis in C. elegans. Nishiwaki K, et al. Nat Cell Biol, 2004 Jan. PMID 14688791
  4. The conserved oligomeric Golgi complex acts in organ morphogenesis via glycosylation of an ADAM protease in C. elegans. Kubota Y, et al. Development, 2006 Jan. PMID 16354716
  5. Broadly conserved roles of TMEM131 family proteins in intracellular collagen assembly and secretory cargo trafficking. Zhang Z, et al. Sci Adv, 2020 Feb. PMID 32095531, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ADP phosphatase activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
enables ADP phosphatase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables GDP phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GDP phosphatase activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
enables GDP phosphatase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables UDP phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables UDP phosphatase activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
enables UDP phosphatase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleoside diphosphate phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables ribonucleoside triphosphate phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in ADP catabolic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in ADP catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in CTP metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in GDP catabolic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in GDP catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in UDP catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in UDP catabolic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in UDP catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in gonad morphogenesis IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in gonad morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in gonadal mesoderm development IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of protein glycosylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of cell migration IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of cell migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi membrane ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Nucleoside-diphosphatase mig-23
NP_508994.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    5945813..5948869 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_076593.8 → NP_508994.1  Nucleoside-diphosphatase mig-23 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_508994.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q21815
    Conserved Domains (1) summary
    pfam01150
    Location:35 → 482
    GDA1_CD39; GDA1/CD39 (nucleoside phosphatase) family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q21815.2

Gene LinkOut

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