kin-2 cAMP-dependent protein kinase regulatory subunit [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: kin-2
Official Full Name: cAMP-dependent protein kinase regulatory subunit
Primary source: WormBase:WBGene00002190
Locus tag: CELE_R07E4.6
See related: AllianceGenome:WB:WBGene00002190
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable cAMP binding activity; cAMP-dependent protein kinase inhibitor activity; and protein kinase A catalytic subunit binding activity. Involved in several processes, including medium-term memory; negative regulation of oocyte maturation; and negative regulation of protein kinase C signaling. Located in cytosol and membrane. Part of cAMP-dependent protein kinase complex. Is expressed in body wall musculature; hypodermis; and intestine. Human ortholog(s) of this gene implicated in Carney complex; acrodysostosis; and primary pigmented nodular adrenocortical disease 1. Orthologous to several human genes including PRKAR1B (protein kinase cAMP-dependent type I regulatory subunit beta). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See kin-2 in Genome Data Viewer

Location:: chromosome: X

Exon count:: 9

Sequence:: Chromosome: X; NC_003284.9 (5970647..5977854, complement)

Chromosome X - NC_003284.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

R07E4.6 (e-PCR)
- UniSTS:314763

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables cAMP binding	IBA Inferred from Biological aspect of Ancestor more info
enables cAMP binding	IEA Inferred from Electronic Annotation more info
enables cAMP-dependent protein kinase inhibitor activity	IBA Inferred from Biological aspect of Ancestor more info
enables cAMP-dependent protein kinase regulator activity	IEA Inferred from Electronic Annotation more info
enables cAMP-dependent protein kinase regulator activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables protein kinase A catalytic subunit binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in medium-term memory	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of oocyte maturation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of protein kinase C signaling	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of positive regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of establishment of cell polarity	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of protein phosphorylation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of cAMP-dependent protein kinase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of cAMP-dependent protein kinase complex	IDA Inferred from Direct Assay more info	PubMed
part_of cAMP-dependent protein kinase complex	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: cAMP-dependent protein kinase regulatory subunit

NP_001024842.1

Confirmed by transcript evidence

NP_001076771.1

Partially confirmed by transcript evidence

NP_001379808.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003284.9 Reference assembly

Range

5970647..5977854 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001392782.1 → NP_001379808.1 cAMP-dependent protein kinase regulatory subunit [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/Swiss-Prot

P30625, Q0MQ68, Q21820, Q95ZR1

Conserved Domains (2) summary

cd12097
Location:13 → 56

DD_RI_PKA; Dimerization/Docking domain of the Type I Regulatory subunit of cAMP-dependent protein kinase

cd00038
Location:122 → 231

CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
NM_001029671.6 → NP_001024842.1 cAMP-dependent protein kinase regulatory subunit [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001024842.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P30625

Conserved Domains (2) summary

COG0664
Location:84 → 239

Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]

cd00038
Location:90 → 199

CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
NM_001083302.4 → NP_001076771.1 cAMP-dependent protein kinase regulatory subunit [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001076771.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P30625

Conserved Domains (3) summary

cd12097
Location:23 → 66

DD_RI_PKA; Dimerization/Docking domain of the Type I Regulatory subunit of cAMP-dependent protein kinase

COG0664
Location:126 → 281

Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]

cd00038
Location:132 → 241

CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...