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mup-2 [ Caenorhabditis elegans ]

Gene ID: 180914, updated on 22-Aug-2024

Summary

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Official Symbol
mup-2
Primary source
WormBase:WBGene00003495
Locus tag
CELE_T22E5.5
See related
AllianceGenome:WB:WBGene00003495
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable tropomyosin binding activity. Involved in several processes, including axonal fasciculation; larval somatic muscle development; and sarcomere organization. Predicted to be part of troponin complex. Human ortholog(s) of this gene implicated in distal arthrogryposis type 2B; distal arthrogryposis type 2B2; and nemaline myopathy 5. Orthologous to human TNNT1 (troponin T1, slow skeletal type) and TNNT3 (troponin T3, fast skeletal type). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: X
Exon count:
6
Sequence:
Chromosome: X; NC_003284.9 (6408471..6410227, complement)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Amino acid transporter;Putative sodium-dependent excitatory amino acid transporter glt-4 Neighboring gene ncRNA Neighboring gene Accessory protein 7b;Zf-C5HC2 domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Developmental genetic analysis of troponin T mutations in striated and nonstriated muscle cells of Caenorhabditis elegans. Myers CD, et al. J Cell Biol, 1996 Mar. PMID 8601585, Free PMC Article
  2. Mutations affecting nerve attachment of Caenorhabditis elegans. Shioi G, et al. Genetics, 2001 Apr. PMID 11290717, Free PMC Article
  3. A local, high-density, single-nucleotide polymorphism map used to clone Caenorhabditis elegans cdf-1. Jakubowski J, et al. Genetics, 1999 Oct. PMID 10511554, Free PMC Article
  4. Ca2+-dependent muscle dysfunction caused by mutation of the Caenorhabditis elegans troponin T-1 gene. McArdle K, et al. J Cell Biol, 1998 Nov 30. PMID 9832549, Free PMC Article
  5. The POU gene ceh-18 promotes gonadal sheath cell differentiation and function required for meiotic maturation and ovulation in Caenorhabditis elegans. Rose KL, et al. Dev Biol, 1997 Dec 1. PMID 9405097

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables tropomyosin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in axonal fasciculation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in embryonic morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in larval somatic muscle development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in muscle contraction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ovulation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of muscle contraction IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of muscle contraction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in sarcomere organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in sarcomere organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of troponin complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of troponin complex IEA
Inferred from Electronic Annotation
more info
  
part_of troponin complex ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 

General protein information

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Preferred Names
Troponin T
NP_509076.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    6408471..6410227 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_076675.10 → NP_509076.1  Troponin T [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_509076.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q27371
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q27371.1

Gene LinkOut

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