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abts-4 Anion exchange protein [ Caenorhabditis elegans ]

Gene ID: 180943, updated on 2-Nov-2024

Summary

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Official Symbol
abts-4
Official Full Name
Anion exchange protein
Primary source
WormBase:WBGene00019844
Locus tag
CELE_R03E9.3
See related
AllianceGenome:WB:WBGene00019844
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable transmembrane transporter activity. Predicted to be involved in bicarbonate transport; regulation of intracellular pH; and transmembrane transport. Located in basolateral plasma membrane. Is expressed in intestine and nervous system. Human ortholog(s) of this gene implicated in congenital hemolytic anemia; hereditary spherocytosis; osteopetrosis; and renal tubular acidosis. Orthologous to several human genes including SLC4A2 (solute carrier family 4 member 2) and SLC4A3 (solute carrier family 4 member 3). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See abts-4 in Genome Data Viewer
Location:
chromosome: X
Exon count:
20
Sequence:
Chromosome: X; NC_003284.9 (6747296..6761738, complement)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Mad-like protein 1 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Inward rectifier potassium channel irk-1 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The abts and sulp families of anion transporters from Caenorhabditis elegans. Sherman T, et al. Am J Physiol Cell Physiol, 2005 Aug. PMID 15814591
  2. Glial regulators of ions and solutes required for specific chemosensory functions in Caenorhabditis elegans. Wang L, et al. iScience, 2022 Dec 22. PMID 36567707, Free PMC Article
  3. Amino acid and protein specificity of protein fatty acylation in C. elegans. Zhang B, et al. Proc Natl Acad Sci U S A, 2024 Jan 30. PMID 38252833, Free PMC Article
  4. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
  5. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables monoatomic anion transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables solute:inorganic anion antiporter activity IEA
Inferred from Electronic Annotation
more info
  
enables transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in bicarbonate transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in inorganic anion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in monoatomic anion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in monoatomic anion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of intracellular pH IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in basolateral plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Anion exchange protein
NP_001024826.2
  • Confirmed by transcript evidence
NP_001123169.1
  • Partially confirmed by transcript evidence
NP_001123170.1
  • Partially confirmed by transcript evidence
NP_001380003.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    6747296..6761738 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001029655.6 → NP_001024826.2  Anion exchange protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001024826.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q58QG8
    Conserved Domains (3) summary
    TIGR00834
    Location:81 → 955
    ae; anion exchange protein
    pfam07565
    Location:100 → 365
    Band_3_cyto; Band 3 cytoplasmic domain
    cl23746
    Location:415 → 879
    HCO3_cotransp; HCO3- transporter family

  2. NM_001129697.5 → NP_001123169.1  Anion exchange protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001123169.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q58G79
    Conserved Domains (3) summary
    TIGR00834
    Location:81 → 935
    ae; anion exchange protein
    pfam07565
    Location:186 → 365
    Band_3_cyto; Band 3 cytoplasmic domain
    cl23746
    Location:415 → 873
    HCO3_cotransp; HCO3- transporter family

  3. NM_001392793.1 → NP_001380003.1  Anion exchange protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q45EK3
    Conserved Domains (1) summary
    cl23746
    Location:414 → 865
    Xan_ur_permease; Permease family

  4. NM_001129698.4 → NP_001123170.1  Anion exchange protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001123170.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    H2L0C4
    Conserved Domains (3) summary
    TIGR00834
    Location:81 → 873
    ae; anion exchange protein
    pfam07565
    Location:186 → 365
    Band_3_cyto; Band 3 cytoplasmic domain
    cl23746
    Location:415 → 873
    HCO3_cotransp; HCO3- transporter family
Nucleotide Protein
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