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atg-2 Autophagy-related protein 2 [ Caenorhabditis elegans ]

Gene ID: 180949, updated on 2-Nov-2024

Summary

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Official Symbol
atg-2
Official Full Name
Autophagy-related protein 2
Primary source
WormBase:WBGene00019748
Locus tag
CELE_M03A8.2
See related
AllianceGenome:WB:WBGene00019748
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable phosphatidylinositol-3-phosphate binding activity and protein-membrane adaptor activity. Involved in positive regulation of autophagy. Predicted to be located in endoplasmic reticulum membrane; lipid droplet; and phagophore assembly site membrane. Predicted to be active in phagophore and phagophore assembly site. Is expressed in several structures, including intestine; nervous system; pharynx; seam cell; and spermathecal-uterine junction. Orthologous to several human genes including ATG2A (autophagy related 2A). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See atg-2 in Genome Data Viewer
Location:
chromosome: X
Exon count:
14
Sequence:
Chromosome: X; NC_003284.9 (6809095..6817214)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene TLDc domain-containing protein Neighboring gene ncRNA Neighboring gene SCP2 domain-containing protein Neighboring gene GEX Interacting protein Neighboring gene ZM domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. HLH-30/TFEB mediates sexual dimorphism in immunity in Caenorhabditis elegans. Sohn J, et al. Autophagy, 2024 Jul 20. PMID 38963038
  2. The WD40 repeat PtdIns(3)P-binding protein EPG-6 regulates progression of omegasomes to autophagosomes. Lu Q, et al. Dev Cell, 2011 Aug 16. PMID 21802374
  3. PI3P phosphatase activity is required for autophagosome maturation and autolysosome formation. Wu Y, et al. EMBO Rep, 2014 Sep. PMID 25124690, Free PMC Article
  4. Autophagy genes function in apoptotic cell corpse clearance during C. elegans embryonic development. Huang S, et al. Autophagy, 2013 Feb 1. PMID 23108454, Free PMC Article
  5. The two C. elegans ATG-16 homologs have partially redundant functions in the basal autophagy pathway. Zhang H, et al. Autophagy, 2013 Dec. PMID 24185444, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables phosphatidylinositol-3-phosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein-membrane adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in autophagosome assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in autophagy IEA
Inferred from Electronic Annotation
more info
  
involved_in autophagy of mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glycophagy IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in lipid transport IEA
Inferred from Electronic Annotation
more info
  
involved_in pexophagy IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in piecemeal microautophagy of the nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of autophagy IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in reticulophagy IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in lipid droplet IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in phagophore IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in phagophore assembly site IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in phagophore assembly site membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Autophagy-related protein 2
NP_509145.3
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    6809095..6817214
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_076744.10 → NP_509145.3  Autophagy-related protein 2 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_509145.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q21480
    Conserved Domains (4) summary
    COG5043
    Location:14 → 185
    MRS6; Vacuolar protein sorting-associated protein [Intracellular trafficking and secretion]
    pfam09333
    Location:2194 → 2279
    ATG_C; Autophagy-related protein C terminal domain
    pfam12624
    Location:15 → 97
    Chorein_N; N-terminal region of Chorein or VPS13
    pfam16909
    Location:2014 → 2171
    VPS13_C; Vacuolar-sorting-associated 13 protein C-terminal
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q21480.3

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