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dhs-28 SCP2 domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 180950, updated on 2-Nov-2024

Summary

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Official Symbol
dhs-28
Official Full Name
SCP2 domain-containing protein
Primary source
WormBase:WBGene00000991
Locus tag
CELE_M03A8.1
See related
AllianceGenome:WB:WBGene00000991
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable 3-hydroxyacyl-CoA dehydrogenase activity and enoyl-CoA hydratase activity. Involved in several processes, including ascaroside biosynthetic process; dauer entry; and pheromone biosynthetic process. Located in peroxisome. Is expressed in hypodermis and intestine. Used to study obesity. Human ortholog(s) of this gene implicated in D-bifunctional protein deficiency; Perrault syndrome; and Stiff-Person syndrome. Orthologous to human HSD17B4 (hydroxysteroid 17-beta dehydrogenase 4). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See dhs-28 in Genome Data Viewer
Location:
chromosome: X
Exon count:
6
Sequence:
Chromosome: X; NC_003284.9 (6818438..6820080)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Autophagy-related protein 2 Neighboring gene GEX Interacting protein Neighboring gene ZM domain-containing protein Neighboring gene Secreted protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Biosynthesis of the Caenorhabditis elegans dauer pheromone. Butcher RA, et al. Proc Natl Acad Sci U S A, 2009 Feb 10. PMID 19174521, Free PMC Article
  2. Caenorhabditis elegans utilizes dauer pheromone biosynthesis to dispose of toxic peroxisomal fatty acids for cellular homoeostasis. Joo HJ, et al. Biochem J, 2009 Jul 29. PMID 19496754
  3. Toxicity of sodium fluoride to Caenorhabditis elegans. Li Q, et al. Biomed Environ Sci, 2012 Apr. PMID 22998830
  4. Comparative metabolomics reveals biogenesis of ascarosides, a modular library of small-molecule signals in C. elegans. von Reuss SH, et al. J Am Chem Soc, 2012 Jan 25. PMID 22239548, Free PMC Article
  5. Peroxisome protein transportation affects metabolism of branched-chain fatty acids that critically impact growth and development of C. elegans. Wang R, et al. PLoS One, 2013. PMID 24086720, Free PMC Article

See all (33) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables 3-hydroxyacyl-CoA dehydrogenase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables enoyl-CoA hydratase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in acyl-CoA metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ascaroside biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in dauer entry IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in fatty acid beta-oxidation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of lipid storage IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in pheromone biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of developmental growth IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of nematode larval development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to pheromone IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in very long-chain fatty acid metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in peroxisome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in peroxisome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in peroxisome IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
SCP2 domain-containing protein
NP_509146.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    6818438..6820080
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_076745.8 → NP_509146.1  SCP2 domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_509146.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q21481
    Conserved Domains (2) summary
    cd05353
    Location:3 → 252
    hydroxyacyl-CoA-like_DH_SDR_c-like; (3R)-hydroxyacyl-CoA dehydrogenase-like, classical(c)-like SDRs
    pfam02036
    Location:325 → 429
    SCP2; SCP-2 sterol transfer family
Nucleotide Protein
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