U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

glr-6 Glutamate receptor ionotropic, kainate 2;Ionotropic glutamate receptor C-terminal domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 180955, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
glr-6
Official Full Name
Glutamate receptor ionotropic, kainate 2;Ionotropic glutamate receptor C-terminal domain-containing protein
Primary source
WormBase:WBGene00001617
Locus tag
CELE_F41B4.4
See related
AllianceGenome:WB:WBGene00001617
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable glutamate receptor activity and transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential. Predicted to be involved in glutamatergic synaptic transmission and modulation of chemical synaptic transmission. Predicted to be located in postsynaptic membrane. Predicted to be active in postsynaptic density membrane. Is expressed in RIAL and RIAR. [provided by Alliance of Genome Resources, Nov 2024]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See glr-6 in Genome Data Viewer
Location:
chromosome: X
Exon count:
13
Sequence:
Chromosome: X; NC_003284.9 (6836210..6840720, complement)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Secreted protein Neighboring gene Proteobacterial sortase system OmpA family protein Neighboring gene putative ATP synthase subunit g 2, mitochondrial Neighboring gene Antifreeze protein;Prion-like-(Q/N-rich)-domain-bearing protein;Secreted protein

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Molecular and circuit mechanisms underlying avoidance of rapid cooling stimuli in C. elegans. Lin C, et al. Nat Commun, 2024 Jan 5. PMID 38182628, Free PMC Article
  2. Transmissions of serotonin, dopamine, and glutamate are required for the formation of neurotoxicity from Al2O3-NPs in nematode Caenorhabditis elegans. Li Y, et al. Nanotoxicology, 2013 Aug. PMID 22548316
  3. Glutamate receptor channel signatures. Sprengel R, et al. Trends Pharmacol Sci, 2001 Jan. PMID 11165660
  4. Functional analysis of Caenorhabditis elegans glutamate receptor subunits by domain transplantation. Strutz-Seebohm N, et al. J Biol Chem, 2003 Nov 7. PMID 12930835
  5. Differential expression of glutamate receptor subunits in the nervous system of Caenorhabditis elegans and their regulation by the homeodomain protein UNC-42. Brockie PJ, et al. J Neurosci, 2001 Mar 1. PMID 11222641, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables glutamate receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ligand-gated monoatomic ion channel activity IEA
Inferred from Electronic Annotation
more info
  
enables monoatomic ion channel activity IEA
Inferred from Electronic Annotation
more info
  
enables signaling receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in modulation of chemical synaptic transmission IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in monoatomic ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of postsynaptic membrane potential IEA
Inferred from Electronic Annotation
more info
  
involved_in synaptic transmission, glutamatergic IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in postsynaptic density membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in postsynaptic membrane IEA
Inferred from Electronic Annotation
more info
  
located_in synapse IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
Glutamate receptor ionotropic, kainate 2;Ionotropic glutamate receptor C-terminal domain-containing protein
NP_001370595.1
  • Confirmed by transcript evidence
NP_741822.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    6836210..6840720 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_171712.5 → NP_741822.2  Glutamate receptor ionotropic, kainate 2 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_741822.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8MXV8
    Conserved Domains (2) summary
    cd13714
    Location:409 → 764
    PBP2_iGluR_Kainate; Kainate receptor of the type 2 periplasmic-binding fold superfamily
    cd06368
    Location:21 → 394
    PBP1_iGluR_non_NMDA-like; N-terminal leucine-isoleucine-valine binding protein (LIVBP)-like domain of the non-NMDA (N-methyl-D-aspartate) subtypes of ionotropic glutamate receptors

  2. NM_001383601.1 → NP_001370595.1  Ionotropic glutamate receptor C-terminal domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8MXV7
    Conserved Domains (1) summary
    cl21456
    Location:110 → 248
    Periplasmic_Binding_Protein_Type_2; Type 2 periplasmic binding fold superfamily
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools
Miscellaneous