U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

F46H5.4 C2 DOCK-type domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 180988, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
F46H5.4
Official Full Name
C2 DOCK-type domain-containing protein
Primary source
WormBase:WBGene00018520
Locus tag
CELE_F46H5.4
See related
AllianceGenome:WB:WBGene00018520
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in regulation of Rho protein signal transduction. Is expressed in body wall musculature. Human ortholog(s) of this gene implicated in several diseases, including Adams-Oliver syndrome; developmental and epileptic encephalopathy 23; hyper IgE recurrent infection syndrome 2; immune dysregulation-polyendocrinopathy-enteropathy-X-linked syndrome; and viral infectious disease (multiple). Orthologous to several human genes including DOCK8 (dedicator of cytokinesis 8). [provided by Alliance of Genome Resources, Nov 2024]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See F46H5.4 in Genome Data Viewer
Location:
chromosome: X
Exon count:
35
Sequence:
Chromosome: X; NC_003284.9 (7245064..7254610, complement)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene putative arginine kinase F46H5.3 Neighboring gene ncRNA Neighboring gene AMPK1_CBM domain-containing protein Neighboring gene MATH domain-containing protein Neighboring gene Beta-lactamase-related domain-containing protein

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article
  2. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

GeneRIFs: Gene References Into Functions

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in regulation of Rho protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in small GTPase-mediated signal transduction IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
C2 DOCK-type domain-containing protein
NP_509219.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    7245064..7254610 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_076818.7 → NP_509219.1  C2 DOCK-type domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_509219.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q20487
    Conserved Domains (3) summary
    cd08696
    Location:589 → 765
    C2_Dock-C; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
    pfam06920
    Location:1488 → 1998
    DHR-2; Dock homology region 2
    pfam11878
    Location:88 → 167
    DUF3398; Domain of unknown function (DUF3398)
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools
Miscellaneous