Nlk nemo like kinase [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Nlkprovided by MGI
Official Full Name: nemo like kinaseprovided by MGI
Primary source: MGI:MGI:1201387
See related: Ensembl:ENSMUSG00000017376 AllianceGenome:MGI:1201387
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Enables several functions, including ATP binding activity; SH2 domain binding activity; and magnesium ion binding activity. Involved in several processes, including peptidyl-threonine phosphorylation; regulation of DNA-templated transcription; and regulation of signal transduction. Acts upstream of or within protein autophosphorylation. Located in nucleus. Is expressed in several structures, including early embryo; genitourinary system; nervous system; neural retina; and respiratory system. Orthologous to human NLK (nemo like kinase). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in cortex adult (RPKM 16.4), frontal lobe adult (RPKM 14.0) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 B5; 11 46.74 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (78457994..78588848, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (78567168..78697595, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Reduction of nemo-like kinase increases lysosome biogenesis and ameliorates TDP-43-related neurodegeneration.
Title: Reduction of nemo-like kinase increases lysosome biogenesis and ameliorates TDP-43-related neurodegeneration.
Nemo-like kinase reduces mutant huntingtin levels and mitigates Huntington's disease.
Title: Nemo-like kinase reduces mutant huntingtin levels and mitigates Huntington's disease.
Diamond Blackfan anemia is mediated by hyperactive Nemo-like kinase.
Title: Diamond Blackfan anemia is mediated by hyperactive Nemo-like kinase.
The phosphatase activity of WIP1 increases Wnt activity through Nemo-like kinase (NLK). WIP1 directly interacted with NLK, which is highly homologous to p38 MAPK, a WIP1 substrate, and dephosphorylated its activation site.
Title: Wip1 directly dephosphorylates NLK and increases Wnt activity during germ cell development.
our data suggest that NLK/Nemo acts as an endogenous regulator of Hippo signaling by controlling nuclear localization and activity of YAP/Yorkie.
Title: Phosphorylation by NLK inhibits YAP-14-3-3-interactions and induces its nuclear localization.
NLK is a novel signaling molecule for proper lung development through the interconnection between epithelial and endothelial cells during lung morphogenesis
Title: Nemo-like kinase regulates the expression of vascular endothelial growth factor (VEGF) in alveolar epithelial cells.
NLK can phosphorylate the mutant polyglutamine-expanded androgen receptor protein, enhance its aggregation, and promote androgen receptor-dependent gene transcription by regulating androgen receptor-cofactor interactions.
Title: Nemo-like kinase is a novel regulator of spinal and bulbar muscular atrophy.
Nlk is a negative regulator of skeletal homeostasis.
Title: Nemo-like kinase regulates postnatal skeletal homeostasis.
either reducing NLK enzymatic activity or decreasing NLK expression levels can have beneficial effects against the toxicity induced by polyglutamine-expanded ATXN1
Title: Polyglutamine disease toxicity is regulated by Nemo-like kinase in spinocerebellar ataxia type 1.
NEMO binding domain peptide treatment results in improved generation of specific force and greater resistance to lengthening activations in dystrophic diaphragm muscle ex vivo.
Title: Systemic delivery of NEMO binding domain/IKKγ inhibitory peptide to young mdx mice improves dystrophic skeletal muscle histopathology.

Submit: New GeneRIF Correction See all GeneRIFs (14)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Gene trapped (2)
Targeted (5) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH135934 (e-PCR)
- UniSTS:209931

NLK_1472 (e-PCR)
- UniSTS:277533

Nlk-ps1 (e-PCR), detects polymorphism
- UniSTS:239188

D11Bhm62 (e-PCR), detects polymorphism
- UniSTS:141667

D11Bhm63 (e-PCR), detects polymorphism
- UniSTS:141668

D11Bhm64 (e-PCR), detects polymorphism
- UniSTS:141669

D11Bhm65 (e-PCR), detects polymorphism
- UniSTS:141670

D11Bhm66 (e-PCR), detects polymorphism
- UniSTS:141671

D11Bhm67 (e-PCR), detects polymorphism
- UniSTS:141672

D11Bhm68 (e-PCR), detects polymorphism
- UniSTS:141673

D11Bhm69 (e-PCR), detects polymorphism
- UniSTS:141674

NoName (e-PCR)
- UniSTS:236651

RH126274 (e-PCR)
- UniSTS:162982

D2Abb1e (e-PCR), detects polymorphism
- UniSTS:142287

D11Seg40 (e-PCR), detects polymorphism
- UniSTS:141816

D11Seg41 (e-PCR), detects polymorphism
- UniSTS:141817

D11Seg42 (e-PCR), detects polymorphism
- UniSTS:141818

D11Seg43 (e-PCR), detects polymorphism
- UniSTS:141819

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor binding	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor binding	ISS Inferred from Sequence or Structural Similarity more info
enables JUN kinase activity	IEA Inferred from Electronic Annotation more info
enables MAP kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables SH2 domain binding	IPI Inferred from Physical Interaction more info	PubMed
enables magnesium ion binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info
enables ubiquitin protein ligase binding	ISO Inferred from Sequence Orthology more info
enables ubiquitin protein ligase binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in JNK cascade	IEA Inferred from Electronic Annotation more info
involved_in Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in cellular response to osmotic stress	IEA Inferred from Electronic Annotation more info
involved_in cellular response to osmotic stress	ISO Inferred from Sequence Orthology more info
involved_in intracellular signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular signal transduction	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of TORC1 signaling	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of TORC1 signaling	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of Wnt signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in peptidyl-threonine phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of receptor signaling pathway via STAT	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within protein autophosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in protein stabilization	ISO Inferred from Sequence Orthology more info
involved_in protein stabilization	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in transforming growth factor beta receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in transforming growth factor beta receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: serine/threonine-protein kinase NLK

NP_032728.3

EC 2.7.11.24

XP_036012300.1

EC 2.7.11.24

XP_036012301.1

EC 2.7.11.24

XP_036012302.1

EC 2.7.11.24

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_008702.3 → NP_032728.3 serine/threonine-protein kinase NLK

See identical proteins and their annotated locations for NP_032728.3

Status: VALIDATED

Source sequence(s)

AK078118, AK160340, BU923375, BY137033, BY237029, CB234984, CO042120

Consensus CDS

CCDS25113.2

UniProtKB/Swiss-Prot

O54949, Q5SYE6, Q6PF98

Related

ENSMUSP00000119345.2, ENSMUST00000142739.8

Conserved Domains (1) summary

cd07853
Location:137 → 508

STKc_NLK; Catalytic domain of the Serine/Threonine Kinase, Nemo-Like Kinase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

78457994..78588848 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036156409.1 → XP_036012302.1 serine/threonine-protein kinase NLK isoform X3

Conserved Domains (1) summary

cl21453
Location:1 → 287

PKc_like; Protein Kinases, catalytic domain
XM_036156408.1 → XP_036012301.1 serine/threonine-protein kinase NLK isoform X2

Conserved Domains (1) summary

cd07853
Location:2 → 356

STKc_NLK; Catalytic domain of the Serine/Threonine Kinase, Nemo-Like Kinase
XM_036156407.1 → XP_036012300.1 serine/threonine-protein kinase NLK isoform X1

Conserved Domains (1) summary

cd07853
Location:22 → 376

STKc_NLK; Catalytic domain of the Serine/Threonine Kinase, Nemo-Like Kinase