U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

epg-7 Autophagy-related protein 11 C-terminal domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 180996, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
epg-7
Official Full Name
Autophagy-related protein 11 C-terminal domain-containing protein
Primary source
WormBase:WBGene00020334
Locus tag
CELE_T08A9.1
See related
AllianceGenome:WB:WBGene00020334
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables molecular adaptor activity. Involved in positive regulation of macroautophagy. Located in cytoplasm. Is expressed in neurons; pharyngeal muscle cell; and tail. Human ortholog(s) of this gene implicated in breast cancer. Orthologous to human RB1CC1 (RB1 inducible coiled-coil 1). [provided by Alliance of Genome Resources, Nov 2024]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See epg-7 in Genome Data Viewer
Location:
chromosome: X
Exon count:
14
Sequence:
Chromosome: X; NC_003284.9 (7334714..7340268)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Transthyretin-like family protein Neighboring gene TransThyretin-Related family domain Neighboring gene NADP-dependent oxidoreductase domain-containing protein Neighboring gene NADP-dependent oxidoreductase domain-containing protein

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. ALLO-1- and IKKE-1-dependent positive feedback mechanism promotes the initiation of paternal mitochondrial autophagy. Sasaki T, et al. Nat Commun, 2024 Feb 17. PMID 38368448, Free PMC Article
  2. The autophagy receptor ALLO-1 and the IKKE-1 kinase control clearance of paternal mitochondria in Caenorhabditis elegans. Sato M, et al. Nat Cell Biol, 2018 Jan. PMID 29255173
  3. The composition of a protein aggregate modulates the specificity and efficiency of its autophagic degradation. Zhang G, et al. Autophagy, 2017 Sep 2. PMID 28806108, Free PMC Article
  4. Autophagy and beyond: Unraveling the complexity of UNC-51-like kinase 1 (ULK1) from biological functions to therapeutic implications. Zou L, et al. Acta Pharm Sin B, 2022 Oct. PMID 36213540, Free PMC Article
  5. Inositol Polyphosphate Multikinase Inhibits Liquid-Liquid Phase Separation of TFEB to Negatively Regulate Autophagy Activity. Chen D, et al. Dev Cell, 2020 Dec 7. PMID 33290695

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables molecular adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables molecular adaptor activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in autophagosome assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in autophagosome assembly IEA
Inferred from Electronic Annotation
more info
  
involved_in autophagy IEA
Inferred from Electronic Annotation
more info
  
involved_in autophagy of mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glycophagy IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in organelle organization IEA
Inferred from Electronic Annotation
more info
  
involved_in pexophagy IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in piecemeal microautophagy of the nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of macroautophagy IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in reticulophagy IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ribophagy IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of Atg1/ULK1 kinase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in phagophore assembly site membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
Autophagy-related protein 11 C-terminal domain-containing protein
NP_509241.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    7334714..7340268
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_076840.8 → NP_509241.2  Autophagy-related protein 11 C-terminal domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q22342
    Conserved Domains (3) summary
    TIGR02169
    Location:753 → 953
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
    pfam10377
    Location:1233 → 1322
    ATG11; Autophagy-related protein 11
    cl28922
    Location:3 → 78
    Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools
Miscellaneous