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clc-2 Clc-like protein 2 [ Caenorhabditis elegans ]

Gene ID: 180999, updated on 2-Nov-2024

Summary

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Official Symbol
clc-2
Official Full Name
Clc-like protein 2
Primary source
WormBase:WBGene00000523
Locus tag
CELE_C01C10.1
See related
AllianceGenome:WB:WBGene00000523
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Involved in epithelial cell-cell adhesion. Located in plasma membrane. Is expressed in hypodermis. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See clc-2 in Genome Data Viewer
Location:
chromosome: X
Exon count:
7
Sequence:
Chromosome: X; NC_003284.9 (7431465..7433535)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Clc-like protein 5 Neighboring gene MYM-type domain-containing protein Neighboring gene Putative 1-acyl-sn-glycerol-3-phosphate acyltransferase acl-12

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The voltage-gated anion channels encoded by clh-3 regulate egg laying in C. elegans by modulating motor neuron excitability. Branicky R, et al. J Neurosci, 2014 Jan 15. PMID 24431435, Free PMC Article
  2. Identification and characterization of a new member of the gas3/PMP22 gene family in C. elegans. Agostoni E, et al. Gene, 1999 Jul 8. PMID 10395899
  3. Double the keys, double the control: coupled phosphorylation sites provide novel molecular targets for precise control of ion channel function. Focus on "Differential regulation of a CLC anion channel by SPAK kinase ortholog-mediated multisite phosphorylation". Duan DD, et al. Am J Physiol Cell Physiol, 2012 Jun 15. PMID 22496246, Free PMC Article
  4. Claudins in Caenorhabditis elegans: their distribution and barrier function in the epithelium. Asano A, et al. Curr Biol, 2003 Jun 17. PMID 12814550
  5. Claudin family proteins in Caenorhabditis elegans. Simske JS, et al. Methods Mol Biol, 2011. PMID 21717355

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in epithelial cell-cell adhesion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane NAS
Non-traceable Author Statement
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Clc-like protein 2
NP_001362078.1
  • Confirmed by transcript evidence
NP_509257.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    7431465..7433535
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001375068.3 → NP_001362078.1  Clc-like protein 2 [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A4V0IK28
    Conserved Domains (1) summary
    pfam07062
    Location:3 → 153
    Clc-like

  2. NM_076856.7 → NP_509257.1  Clc-like protein 2 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_509257.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q11085, Q9NGJ8
    Conserved Domains (1) summary
    pfam07062
    Location:3 → 200
    Clc-like; Clc-like
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q11085.2

Gene LinkOut

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