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AGRP agouti related neuropeptide [ Homo sapiens (human) ]

Gene ID: 181, updated on 2-Nov-2024

Summary

Official Symbol
AGRPprovided by HGNC
Official Full Name
agouti related neuropeptideprovided by HGNC
Primary source
HGNC:HGNC:330
See related
Ensembl:ENSG00000159723 MIM:602311; AllianceGenome:HGNC:330
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ART; AGRT; ASIP2
Summary
This gene encodes an antagonist of the melanocortin-3 and melanocortin-4 receptor. It appears to regulate hypothalamic control of feeding behavior via melanocortin receptor and/or intracellular calcium regulation, and thus plays a role in weight homeostasis. Mutations in this gene have been associated with late on-set obesity. [provided by RefSeq, Dec 2009]
Expression
Biased expression in adrenal (RPKM 1.6), lung (RPKM 0.8) and 5 other tissues See more
Orthologs
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Genomic context

See AGRP in Genome Data Viewer
Location:
16q22.1
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (67482571..67483547, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (73277343..73278319, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (67516474..67517450, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7604 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7605 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:67469389-67469890 Neighboring gene hydroxysteroid 11-beta dehydrogenase 2 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:67477413-67478036 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:67478661-67479284 Neighboring gene ATPase H+ transporting V0 subunit d1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:67481159-67481658 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:67485489-67486172 Neighboring gene Sharpr-MPRA regulatory region 10086 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:67495532-67496032 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:67499338-67499838 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:67499839-67500339 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10965 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10966 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7606 Neighboring gene ATP6V0D1 divergent transcript Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10967 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10968 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:67548235-67548422 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7607 Neighboring gene uncharacterized LOC100505942 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10969 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10970 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10971 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10972 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10973 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7608 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7609 Neighboring gene RHO family interacting cell polarization regulator 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7610 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7611 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:67571987-67572608 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10975 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7613 Neighboring gene Sharpr-MPRA regulatory region 14438 Neighboring gene uncharacterized LOC124903703 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:67586099-67586600 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:67586601-67587100 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10977 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10978 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:67596785-67597647 Neighboring gene CTCF divergent transcript

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Related articles in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Inherited obesity
MedGen: C4054476 OMIM: 601665 GeneReviews: Not available
Compare labs

Pathways from PubChem

Interactions

General gene information

Clone Names

  • MGC118963

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables neuropeptide hormone activity  
enables neuropeptide hormone activity PubMed 
enables signaling receptor binding PubMed 
enables type 1 melanocortin receptor binding  
Process Evidence Code Pubs
involved_in adult feeding behavior  
involved_in circadian rhythm  
involved_in eating behavior  
involved_in feeding behavior PubMed 
involved_in hormone-mediated signaling pathway  
involved_in long-day photoperiodism  
involved_in maternal process involved in female pregnancy  
involved_in neuropeptide signaling pathway  
involved_in neuropeptide signaling pathway PubMed 
involved_in positive regulation of feeding behavior  
involved_in regulation of feeding behavior PubMed 
involved_in regulation of feeding behavior PubMed 
involved_in response to insulin  
Component Evidence Code Pubs
located_in Golgi lumen PubMed 
is_active_in extracellular space  
located_in extracellular space PubMed 
located_in neuronal cell body  

General protein information

Preferred Names
agouti-related protein
Names
agouti related protein homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_011501.1 RefSeqGene

    Range
    5267..6243
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001138.2NP_001129.1  agouti-related protein precursor

    See identical proteins and their annotated locations for NP_001129.1

    Status: REVIEWED

    Source sequence(s)
    AC009061
    Consensus CDS
    CCDS10839.1
    UniProtKB/Swiss-Prot
    O00253, O15459, Q2TBD9
    UniProtKB/TrEMBL
    C6SUN5
    Related
    ENSP00000290953.3, ENST00000290953.3
    Conserved Domains (1) summary
    smart00792
    Location:1122
    Agouti; Agouti protein

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

    Range
    67482571..67483547 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047433694.1XP_047289650.1  agouti-related protein isoform X1

    UniProtKB/Swiss-Prot
    O00253, O15459, Q2TBD9
    UniProtKB/TrEMBL
    C6SUN5

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060940.1 Alternate T2T-CHM13v2.0

    Range
    73277343..73278319 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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