sek-1 Dual specificity mitogen-activated protein kinase kinase sek-1 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: sek-1
Official Full Name: Dual specificity mitogen-activated protein kinase kinase sek-1
Primary source: WormBase:WBGene00004758
Locus tag: CELE_R03G5.2
See related: AllianceGenome:WB:WBGene00004758
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables MAP kinase kinase activity; mitogen-activated protein kinase kinase kinase binding activity; and protein serine kinase activity. Involved in several processes, including defense response to other organism; p38MAPK cascade; and positive regulation of macromolecule biosynthetic process. Is expressed in excretory canal; linker cell; neurons; rectal epithelium; and uterine-vulval cell. Used to study Parkinson's disease. Human ortholog(s) of this gene implicated in Pick's disease; cervical cancer; ovarian carcinoma; progressive supranuclear palsy; and restrictive cardiomyopathy. Orthologous to human MAP2K3 (mitogen-activated protein kinase kinase 3) and MAP2K6 (mitogen-activated protein kinase kinase 6). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See sek-1 in Genome Data Viewer

Location:: chromosome: X

Exon count:: 7

Sequence:: Chromosome: X; NC_003284.9 (7816734..7821036)

Chromosome X - NC_003284.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

this study shows that sek-1(-) MAP kinase mutant nematodes succumb to infection faster, suggesting that this signaling pathway plays a role in immune activation
Title: Analysis of the Caenorhabditis elegans innate immune response to Coxiella burnetii.
SEK-1 is key player involved in tannic acid (TA)-mediated longevity. It is conceivable that TA mimics pathogen action and therefore activates the SEK-1-mediated pathogen resistance pathway.
Title: The longevity effect of tannic acid in Caenorhabditis elegans: Disposable Soma meets hormesis.
Reuslts identify four genes to be required for the quercetin derived lifespan extension in C. elegans, namely age-1, daf-2, unc-43 and sek-1.
Title: Quercetin mediated lifespan extension in Caenorhabditis elegans is modulated by age-1, daf-2, sek-1 and unc-43.
oxidative, osmotic, heat shock and starvation stresses induce germ cell apoptosis through a p53 and EGL-1 independent pathway; the MAPK kinases MEK-1 and SEK-1, and the p53 antagonist protein ABL-1, are essential for stress-induced germ cell apoptosis
Title: Stress-induced germ cell apoptosis by a p53 independent pathway in Caenorhabditis elegans.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

R03G5.2 (e-PCR)
- UniSTS:312418

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables MAP kinase kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables MAP kinase kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables MAP kinase kinase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables mitogen-activated protein kinase kinase kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine kinase activity	IGI Inferred from Genetic Interaction more info	PubMed
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine/tyrosine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein tyrosine kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in MAPK cascade	IGI Inferred from Genetic Interaction more info	PubMed
involved_in MAPK cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in antibacterial innate immune response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in defense response to Gram-negative bacterium	IGI Inferred from Genetic Interaction more info	PubMed
involved_in defense response to Gram-negative bacterium	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in defense response to Gram-positive bacterium	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in defense response to fungus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in determination of left/right asymmetry in nervous system	IGI Inferred from Genetic Interaction more info	PubMed
involved_in determination of left/right asymmetry in nervous system	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in innate immune response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nervous system development	IEA Inferred from Electronic Annotation more info
involved_in p38MAPK cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in peptidyl-serine phosphorylation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of egg-laying behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in regulation of egg-laying behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to nematicide	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to oxidative stress	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to reactive oxygen species	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to stimulus	IEA Inferred from Electronic Annotation more info
involved_in response to superoxide	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to toxic substance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in stress-activated MAPK cascade	IBA Inferred from Biological aspect of Ancestor more info
involved_in turning behavior involved in mating	IMP Inferred from Mutant Phenotype more info	PubMed

General protein information

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Preferred Names: Dual specificity mitogen-activated protein kinase kinase sek-1

NP_509322.2

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003284.9 Reference assembly

Range

7816734..7821036

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_076921.8 → NP_509322.2 Dual specificity mitogen-activated protein kinase kinase sek-1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_509322.2

Status: REVIEWED

UniProtKB/Swiss-Prot

G5EDF7

Conserved Domains (2) summary

cd06617
Location:48 → 328

PKc_MKK3_6; Catalytic domain of the dual-specificity Protein Kinases, Mitogen-activated protein Kinase Kinases 3 and 6

smart00220
Location:52 → 311

S_TKc; Serine/Threonine protein kinases, catalytic domain