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eef-1A.2 Elongation factor 1-alpha [ Caenorhabditis elegans ]

Gene ID: 181044, updated on 2-Nov-2024

Summary

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Official Symbol
eef-1A.2
Official Full Name
Elongation factor 1-alpha
Primary source
WormBase:WBGene00001169
Locus tag
CELE_R03G5.1
See related
AllianceGenome:WB:WBGene00001169
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable GTP binding activity; GTPase activity; and translation elongation factor activity. Predicted to be involved in translational elongation. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 38; developmental and epileptic encephalopathy 33; and ovarian cancer. Orthologous to human EEF1A1 (eukaryotic translation elongation factor 1 alpha 1); EEF1A1P5 (eukaryotic translation elongation factor 1 alpha 1 pseudogene 5); and EEF1A2 (eukaryotic translation elongation factor 1 alpha 2). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See eef-1A.2 in Genome Data Viewer
Location:
chromosome: X
Exon count:
3
Sequence:
Chromosome: X; NC_003284.9 (7823654..7825769)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Dual specificity mitogen-activated protein kinase kinase sek-1 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Sulfatase N-terminal domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Characterization of the biochemical activity and tumor-promoting role of the dual protein methyltransferase METL-13/METTL13 in Caenorhabditis elegans. Engelfriet ML, et al. PLoS One, 2023. PMID 37347777, Free PMC Article
  2. The Caenorhabditis elegans Protein FIC-1 Is an AMPylase That Covalently Modifies Heat-Shock 70 Family Proteins, Translation Elongation Factors and Histones. Truttmann MC, et al. PLoS Genet, 2016 May. PMID 27138431, Free PMC Article
  3. Autosomal genes of autosomal/X-linked duplicated gene pairs and germ-line proliferation in Caenorhabditis elegans. Maciejowski J, et al. Genetics, 2005 Apr. PMID 15687263, Free PMC Article
  4. Mass spectrometry-based shotgun proteomic analysis of C. elegans protein complexes. Fonslow BR, et al. WormBook, 2014 Jun 24. PMID 24967700, Free PMC Article
  5. An analysis of the Caenorhabditis elegans lipid raft proteome using geLC-MS/MS. Rao W, et al. J Proteomics, 2011 Feb 1. PMID 21070894

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
  
enables translation elongation factor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in translational elongation IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Elongation factor 1-alpha
NP_509323.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    7823654..7825769
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_076922.5 → NP_509323.1  Elongation factor 1-alpha [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_509323.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P53013
    Conserved Domains (4) summary
    PTZ00141
    Location:1 → 461
    PTZ00141; elongation factor 1- alpha; Provisional
    cd01883
    Location:9 → 239
    EF1_alpha; Elongation Factor 1-alpha (EF1-alpha) protein family
    cd03693
    Location:242 → 332
    EF1_alpha_II; Domain II of elongation factor 1-alpha
    cd03705
    Location:335 → 438
    EF1_alpha_III; Domain III of Elongation Factor 1
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P53013.1

Gene LinkOut

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