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tnt-2 Troponin T [ Caenorhabditis elegans ]

Gene ID: 181119, updated on 2-Nov-2024

Summary

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Official Symbol
tnt-2
Official Full Name
Troponin T
Primary source
WormBase:WBGene00006587
Locus tag
CELE_F53A9.10
See related
AllianceGenome:WB:WBGene00006587
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable tropomyosin binding activity. Predicted to be involved in muscle contraction and sarcomere organization. Predicted to be part of troponin complex. Is expressed in body wall musculature; enteric muscle; and reproductive system. Human ortholog(s) of this gene implicated in intrinsic cardiomyopathy (multiple) and muscle tissue disease (multiple). Orthologous to human TNNT1 (troponin T1, slow skeletal type); TNNT2 (troponin T2, cardiac type); and TNNT3 (troponin T3, fast skeletal type). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See tnt-2 in Genome Data Viewer
Location:
chromosome: X
Exon count:
6
Sequence:
Chromosome: X; NC_003284.9 (8721546..8723550, complement)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Zinc transporter Slc39a7 Neighboring gene Uncharacterized protein Neighboring gene ncRNA Neighboring gene Uncharacterized protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Integration of male mating and feeding behaviors in Caenorhabditis elegans. Gruninger TR, et al. J Neurosci, 2006 Jan 4. PMID 16399684, Free PMC Article
  2. Decreased expression of myogenic transcription factors and myosin heavy chains in Caenorhabditis elegans muscles developed during spaceflight. Higashibata A, et al. J Exp Biol, 2006 Aug. PMID 16888068
  3. Review of the results from the International C. elegans first experiment (ICE-FIRST). Adenle AA, et al. Adv Space Res, 2009 Jul 15. PMID 20161164, Free PMC Article
  4. Identification of conserved pathways of DNA-damage response and radiation protection by genome-wide RNAi. van Haaften G, et al. Curr Biol, 2006 Jul 11. PMID 16824923
  5. Caenorhabditis elegans ALG-1 antimorphic mutations uncover functions for Argonaute in microRNA guide strand selection and passenger strand disposal. Zinovyeva AY, et al. Proc Natl Acad Sci U S A, 2015 Sep 22. PMID 26351692, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables tropomyosin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in muscle contraction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of muscle contraction IEA
Inferred from Electronic Annotation
more info
  
involved_in sarcomere organization IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of troponin complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of troponin complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Troponin T
NP_001024703.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    8721546..8723550 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001029532.4 → NP_001024703.1  Troponin T [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001024703.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7Z072
Nucleotide Protein
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