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unc-27 Troponin I 2 [ Caenorhabditis elegans ]

Gene ID: 181124, updated on 2-Nov-2024

Summary

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Official Symbol
unc-27
Official Full Name
Troponin I 2
Primary source
WormBase:WBGene00006764
Locus tag
CELE_ZK721.2
See related
AllianceGenome:WB:WBGene00006764
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables troponin C binding activity. Involved in locomotion and sarcomere organization. Located in sarcomere. Is expressed in body wall musculature; non-striated muscle; and rectal muscle. Human ortholog(s) of this gene implicated in arthrogryposis multiplex congenita; distal arthrogryposis type 2B1; and intrinsic cardiomyopathy (multiple). Orthologous to human TNNI1 (troponin I1, slow skeletal type); TNNI2 (troponin I2, fast skeletal type); and TNNI3 (troponin I3, cardiac type). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See unc-27 in Genome Data Viewer
Location:
chromosome: X
Exon count:
5
Sequence:
Chromosome: X; NC_003284.9 (8789456..8790621)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene G_PROTEIN_RECEP_F1_2 domain-containing protein Neighboring gene ncRNA Neighboring gene Cholesterol uptake protein 1 Neighboring gene ncRNA Neighboring gene Uncharacterized protein Neighboring gene ncRNA Neighboring gene tRNA-Gly

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Disruption of Caenorhabditis elegans muscle structure and function caused by mutation of troponin I. Burkeen AK, et al. Biophys J, 2004 Feb. PMID 14747334, Free PMC Article
  2. Molecular evolution of troponin I and a role of its N-terminal extension in nematode locomotion. Barnes DE, et al. Cytoskeleton (Hoboken), 2016 Mar. PMID 26849746, Free PMC Article
  3. Troponin I controls ovulatory contraction of non-striated actomyosin networks in the C. elegans somatic gonad. Obinata T, et al. J Cell Sci, 2010 May 1. PMID 20388732, Free PMC Article
  4. Effect of dys-1 mutation on gene expression profile in space-flown Caenorhabditis elegans. Xu D, et al. Muscle Nerve, 2018 Jan 18. PMID 29346705
  5. A decline in transcript abundance for Heterodera glycines homologs of Caenorhabditis elegans uncoordinated genes accompanies its sedentary parasitic phase. Klink VP, et al. BMC Dev Biol, 2007 Apr 19. PMID 17445261, Free PMC Article

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables actin binding IEA
Inferred from Electronic Annotation
more info
  
enables troponin C binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in locomotion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in muscle contraction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in sarcomere organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in sarcomere IDA
Inferred from Direct Assay
more info
 PubMed 
part_of troponin complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of troponin complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Troponin I 2
NP_509488.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    8789456..8790621
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_077087.9 → NP_509488.2  Troponin I 2 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_509488.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q5FBV6, Q9GYF1
    Conserved Domains (1) summary
    pfam00992
    Location:46 → 178
    Troponin; Troponin
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9GYF1.2

Gene LinkOut

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