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tmc-2 TMC domain-containing protein;Transmembrane channel-like protein 2 [ Caenorhabditis elegans ]

Gene ID: 181161, updated on 2-Nov-2024

Summary

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Official Symbol
tmc-2
Official Full Name
TMC domain-containing protein;Transmembrane channel-like protein 2
Primary source
WormBase:WBGene00015177
Locus tag
CELE_B0416.1
See related
AllianceGenome:WB:WBGene00015177
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable mechanosensitive monoatomic ion channel activity. Predicted to be involved in monoatomic ion transmembrane transport. Predicted to be located in plasma membrane. Is expressed in body wall musculature and vulval muscle. Orthologous to human TMC3 (transmembrane channel like 3). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See tmc-2 in Genome Data Viewer
Location:
chromosome: X
Exon count:
26
Sequence:
Chromosome: X; NC_003284.9 (9303722..9310443)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Uncharacterized protein Neighboring gene TransThyretin-Related family domain

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. TMC Proteins Modulate Egg Laying and Membrane Excitability through a Background Leak Conductance in C. elegans. Yue X, et al. Neuron, 2018 Feb 7. PMID 29395910, Free PMC Article
  2. The structure of the Caenorhabditis elegans TMC-2 complex suggests roles of lipid-mediated subunit contacts in mechanosensory transduction. Clark S, et al. Proc Natl Acad Sci U S A, 2024 Feb 20. PMID 38354260, Free PMC Article
  3. tmc-1 encodes a sodium-sensitive channel required for salt chemosensation in C. elegans. Chatzigeorgiou M, et al. Nature, 2013 Feb 7. PMID 23364694, Free PMC Article
  4. The nematode C. elegans senses airborne sound. Iliff AJ, et al. Neuron, 2021 Nov 17. PMID 34555314, Free PMC Article
  5. Transcriptomics of ivermectin response in Caenorhabditis elegans: Integrating abamectin quantitative trait loci and comparison to the Ivermectin-exposed DA1316 strain. Dube F, et al. PLoS One, 2023. PMID 37141255, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The structure of the Caenorhabditis elegans TMC-2 complex suggests roles of lipid-mediated subunit contacts in mechanosensory transduction.
    Title: The structure of the Caenorhabditis elegans TMC-2 complex suggests roles of lipid-mediated subunit contacts in mechanosensory transduction.
  2. Study found that the C. elegans TMC-1 is expressed in both neurons and muscle cells, while TMC-2 is exclusively expressed in muscle cells. TMC proteins modulate egg laying and membrane excitability through a background leak conductance.
    Title: TMC Proteins Modulate Egg Laying and Membrane Excitability through a Background Leak Conductance in C. elegans.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables mechanosensitive monoatomic ion channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in monoatomic ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
TMC domain-containing protein;Transmembrane channel-like protein 2
NP_001335510.1
  • Confirmed by transcript evidence
NP_001335564.1
  • Confirmed by transcript evidence
NP_001335565.1
  • Confirmed by transcript evidence
NP_001335566.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    9303722..9310443
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001348602.4 → NP_001335564.1  TMC domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q11069
    UniProtKB/TrEMBL
    A0A1N7SYS6
    Conserved Domains (1) summary
    pfam07810
    Location:594 → 709
    TMC; TMC domain

  2. NM_001348601.5 → NP_001335510.1  Transmembrane channel-like protein 2 [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q11069
    Conserved Domains (1) summary
    pfam07810
    Location:594 → 709
    TMC; TMC domain

  3. NM_001348603.4 → NP_001335565.1  TMC domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1N7SYT6
    Conserved Domains (1) summary
    pfam07810
    Location:294 → 409
    TMC; TMC domain

  4. NM_001348604.4 → NP_001335566.1  TMC domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1N7SZ06
    Conserved Domains (1) summary
    pfam07810
    Location:294 → 409
    TMC; TMC domain
Nucleotide Protein
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