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flp-3 TPLGTMRF-amide [ Caenorhabditis elegans ]

Gene ID: 181221, updated on 2-Nov-2024

Summary

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Official Symbol
flp-3
Official Full Name
TPLGTMRF-amide
Primary source
WormBase:WBGene00001446
Locus tag
CELE_W07E11.2
See related
AllianceGenome:WB:WBGene00001446
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Involved in negative regulation of action potential; neuropeptide signaling pathway; and regulation of nematode pharyngeal pumping. Predicted to be located in extracellular region. Is expressed in head; neurons; somatic nervous system; and in male. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See flp-3 in Genome Data Viewer
Location:
chromosome: X
Exon count:
4
Sequence:
Chromosome: X; NC_003284.9 (10091946..10092964, complement)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene glutamate synthase (NADH) Neighboring gene ncRNA Neighboring gene FMRF-Like Peptide Neighboring gene SPREPIRF-amide Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The Architect of Neurotransmission in C. elegans : How FLP-3 Neuropeptides' Structures Direct their Function. Salama R, et al. MicroPubl Biol, 2023. PMID 37396794, Free PMC Article
  2. FMRFamide-like peptides encoded on the flp-18 precursor gene activate two isoforms of the orphan Caenorhabditis elegans G-protein-coupled receptor Y58G8A.4 heterologously expressed in mammalian cells. Kubiak TM, et al. Biopolymers, 2008. PMID 17879267
  3. FMRFamide-related neuropeptide gene family in Caenorhabditis elegans. Li C, et al. Brain Res, 1999 Nov 27. PMID 10612695
  4. The CCAAT-box transcription factor, NF-Y complex, mediates the specification of the IL1 neurons in C. elegans. Heo W, et al. BMB Rep, 2023 Mar. PMID 36330709, Free PMC Article
  5. Zic-Proteins Are Repressors of Dopaminergic Forebrain Fate in Mice and C. elegans. Tiveron MC, et al. J Neurosci, 2017 Nov 1. PMID 28972122, Free PMC Article

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by WormBase

Process Evidence Code Pubs
involved_in negative regulation of action potential IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in neuropeptide signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in neuropeptide signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of nematode pharyngeal pumping IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
TPLGTMRF-amide
NP_509694.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    10091946..10092964 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_077293.8 → NP_509694.1  TPLGTMRF-amide [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_509694.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q23212
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q23212.1

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