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unc-58 Potassium channel domain-containing protein;Uncoordinated protein 58 [ Caenorhabditis elegans ]

Gene ID: 181224, updated on 2-Nov-2024

Summary

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Official Symbol
unc-58
Official Full Name
Potassium channel domain-containing protein;Uncoordinated protein 58
Primary source
WormBase:WBGene00006792
Locus tag
CELE_T06H11.1
See related
AllianceGenome:WB:WBGene00006792
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables outward rectifier potassium channel activity. Involved in several processes, including muscle contraction; parturition; and regulation of muscle contraction. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in interneuron and motor neurons. Orthologous to human KCNK17 (potassium two pore domain channel subfamily K member 17) and KCNK5 (potassium two pore domain channel subfamily K member 5). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See unc-58 in Genome Data Viewer
Location:
chromosome: X
Exon count:
22
Sequence:
Chromosome: X; NC_003284.9 (10104610..10133182, complement)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene glutamate synthase (NADH) Neighboring gene SPREPIRF-amide Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene tRNA-Ser Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene tRNA-Arg Neighboring gene ncRNA Neighboring gene tRNA-Arg Neighboring gene MoaB/Mog domain-containing protein Neighboring gene Nose resistant-to-fluoxetine protein N-terminal domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Clozapine, nimodipine and endosulfan differentially suppress behavioral defects caused by gain-of-function mutations in a two-pore domain K(+) channel (UNC-58). Kasap M, et al. Neurosci Res, 2021 Sep. PMID 32681854
  2. Radiation-induced genomic instability in Caenorhabditis elegans. Huumonen K, et al. Mutat Res, 2012 Oct 9. PMID 22796420
  3. Confounds of using the unc-58 selection marker highlights the importance of genotyping co-CRISPR genes. Rawsthorne-Manning H, et al. PLoS One, 2022. PMID 35041685, Free PMC Article
  4. Mutants of a temperature-sensitive two-P domain potassium channel. Kunkel MT, et al. J Neurosci, 2000 Oct 15. PMID 11027209, Free PMC Article
  5. Isolation of null alleles of the Caenorhabditis elegans gly-12, gly-13 and gly-14 genes, all of which encode UDP-GlcNAc: alpha-3-D-mannoside beta1,2-N-acetylglucosaminyltransferase I activity. Chen S, et al. Biochimie, 2003 Mar-Apr. PMID 12770777

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables outward rectifier potassium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables outward rectifier potassium channel activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables potassium channel activity IEA
Inferred from Electronic Annotation
more info
  
enables potassium ion leak channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in locomotion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in monoatomic ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in muscle contraction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in parturition IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in potassium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in potassium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of muscle contraction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Potassium channel domain-containing protein;Uncoordinated protein 58
NP_001360790.1
  • Confirmed by transcript evidence
NP_001360791.1
  • Partially confirmed by transcript evidence
NP_001360792.1
  • Partially confirmed by transcript evidence
NP_001360793.1
  • Partially confirmed by transcript evidence
NP_001360794.1
  • Confirmed by transcript evidence
NP_741880.1
  • Confirmed by transcript evidence
NP_741881.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    10104610..10133182 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_171759.6 → NP_741881.1  Uncoordinated protein 58 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_741881.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q22271, Q8MPX9
    Conserved Domains (1) summary
    pfam07885
    Location:284 → 344
    Ion_trans_2; Ion channel

  2. NM_001373458.4 → NP_001360790.1  Potassium channel domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A4V0IKM3
    Conserved Domains (1) summary
    pfam07885
    Location:211 → 267
    Ion_trans_2; Ion channel

  3. NM_001373459.2 → NP_001360794.1  Potassium channel domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A4V0INP7
    Conserved Domains (1) summary
    pfam07885
    Location:207 → 263
    Ion_trans_2; Ion channel

  4. NM_001373460.3 → NP_001360792.1  Potassium channel domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A4V0IL39
    Conserved Domains (1) summary
    pfam07885
    Location:184 → 240
    Ion_trans_2; Ion channel

  5. NM_001373456.2 → NP_001360793.1  Potassium channel domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A4V0INX3
    Conserved Domains (1) summary
    pfam07885
    Location:299 → 355
    Ion_trans_2; Ion channel

  6. NM_171758.5 → NP_741880.1  Uncoordinated protein 58 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_741880.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q22271
    Conserved Domains (1) summary
    pfam07885
    Location:246 → 306
    Ion_trans_2; Ion channel

  7. NM_001373457.2 → NP_001360791.1  Potassium channel domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A4V0IKI8
    Conserved Domains (1) summary
    pfam07885
    Location:259 → 315
    Ion_trans_2; Ion channel
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q22271.2

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