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moc-1 MoaB/Mog domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 181225, updated on 2-Nov-2024

Summary

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Official Symbol
moc-1
Official Full Name
MoaB/Mog domain-containing protein
Primary source
WormBase:WBGene00003384
Locus tag
CELE_T06H11.4
See related
AllianceGenome:WB:WBGene00003384
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable molybdopterin molybdotransferase activity. Predicted to be involved in Mo-molybdopterin cofactor biosynthetic process; postsynaptic neurotransmitter receptor diffusion trapping; and synapse organization. Predicted to be located in postsynaptic specialization membrane. Predicted to be active in several cellular components, including dendrite; postsynaptic membrane; and postsynaptic specialization. Is expressed in body wall musculature; intestine; pharyngeal gland cell; reproductive system; and tail. Human ortholog(s) of this gene implicated in inherited metabolic disorder and molybdenum cofactor deficiency type C. Orthologous to human GPHN (gephyrin). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See moc-1 in Genome Data Viewer
Location:
chromosome: X
Exon count:
7
Sequence:
Chromosome: X; NC_003284.9 (10136129..10138620, complement)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Potassium channel domain-containing protein;Uncoordinated protein 58 Neighboring gene ncRNA Neighboring gene tRNA-Arg Neighboring gene ncRNA Neighboring gene tRNA-Arg Neighboring gene Nose resistant-to-fluoxetine protein N-terminal domain-containing protein Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Molybdenum cofactor transfer from bacteria to nematode mediates sulfite detoxification. Warnhoff K, et al. Nat Chem Biol, 2019 May. PMID 30911177, Free PMC Article
  2. Interactome analysis of Caenorhabditis elegans synapses by TurboID-based proximity labeling. Artan M, et al. J Biol Chem, 2021 Sep. PMID 34416233, Free PMC Article
  3. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article
  4. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
  5. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables molybdopterin adenylyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables molybdopterin molybdotransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables molybdopterin molybdotransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in Mo-molybdopterin cofactor biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in Mo-molybdopterin cofactor biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in establishment of synaptic specificity at neuromuscular junction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in gamma-aminobutyric acid receptor clustering IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glycine receptor clustering IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in molybdopterin cofactor biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in postsynaptic neurotransmitter receptor diffusion trapping IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in dendrite IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in postsynaptic membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in postsynaptic specialization IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in postsynaptic specialization membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
MoaB/Mog domain-containing protein
NP_509700.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    10136129..10138620 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_077299.7 → NP_509700.2  MoaB/Mog domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_509700.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5EGH2
    Conserved Domains (1) summary
    cd00887
    Location:18 → 429
    MoeA; MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and ...
Nucleotide Protein
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