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myrf-2 Myelin regulatory factor homolog 2, N-terminal [ Caenorhabditis elegans ]

Gene ID: 181229, updated on 2-Nov-2024

Summary

Official Symbol
myrf-2
Official Full Name
Myelin regulatory factor homolog 2, N-terminal
Primary source
WormBase:WBGene00008999
Locus tag
CELE_F21A10.2
See related
AllianceGenome:WB:WBGene00008999
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable DNA-binding transcription factor activity and sequence-specific DNA binding activity. Predicted to be involved in positive regulation of DNA-templated transcription and protein autoprocessing. Predicted to be located in apical plasma membrane and endoplasmic reticulum. Predicted to be active in endoplasmic reticulum membrane and nucleus. Human ortholog(s) of this gene implicated in cerebral infarction; congenital diaphragmatic hernia; hyperopia; nanophthalmos; and primary angle-closure glaucoma. Orthologous to human MYRF (myelin regulatory factor) and MYRFL (myelin regulatory factor like). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

See myrf-2 in Genome Data Viewer
Location:
chromosome: X
Exon count:
13
Sequence:
Chromosome: X; NC_003284.9 (10180958..10194377, complement)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene SCP domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene EF-hand domain-containing protein Neighboring gene Arrestin C-terminal-like domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene NUCleoBindin homolog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables DNA-binding transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
 
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in protein autoprocessing IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in protein autoprocessing IEA
Inferred from Electronic Annotation
more info
 
involved_in protein autoprocessing ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in apical plasma membrane IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
Myelin regulatory factor homolog 2, N-terminal
NP_001257095.1
  • Partially confirmed by transcript evidence
NP_001367016.1
  • Confirmed by transcript evidence
NP_001367259.1
  • Confirmed by transcript evidence
NP_001379023.1
  • Confirmed by transcript evidence
NP_509709.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    10180958..10194377 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001392832.1NP_001379023.1  Myelin regulatory factor homolog 2, N-terminal [Caenorhabditis elegans]

    Status: REVIEWED

    Conserved Domains (3) summary
    pfam05224
    Location:252402
    NDT80_PhoG; NDT80 / PhoG like DNA-binding family
    pfam13888
    Location:751884
    MRF_C2; Myelin gene regulatory factor C-terminal domain 2
    cl16452
    Location:449557
    Peptidase_S74_CIMCD; Peptidase S74 family, C-terminal intramolecular chaperone domain of Escherichia coli phage K1F endosialidase and related proteins
  2. NM_077308.7NP_509709.2  Myelin regulatory factor homolog 2, N-terminal [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_509709.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D9PTN5
    Conserved Domains (4) summary
    pfam05224
    Location:303453
    NDT80_PhoG; NDT80 / PhoG like DNA-binding family
    pfam13884
    Location:500561
    Peptidase_S74; Chaperone of endosialidase
    pfam13887
    Location:570605
    MRF_C1; Myelin gene regulatory factor -C-terminal domain 1
    pfam13888
    Location:802935
    MRF_C2; Myelin gene regulatory factor C-terminal domain 2
  3. NM_001270166.4NP_001257095.1  Myelin regulatory factor homolog 2, N-terminal [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001257095.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D9PTN4, D9PTN5, G5EF12, Q8MQ67, Q9U3I3
    Conserved Domains (4) summary
    pfam05224
    Location:363513
    NDT80_PhoG; NDT80 / PhoG like DNA-binding family
    pfam13884
    Location:560621
    Peptidase_S74; Chaperone of endosialidase
    pfam13887
    Location:630665
    MRF_C1; Myelin gene regulatory factor -C-terminal domain 1
    pfam13888
    Location:862995
    MRF_C2; Myelin gene regulatory factor C-terminal domain 2
  4. NM_001381079.1NP_001367016.1  Myelin regulatory factor homolog 2, N-terminal [Caenorhabditis elegans]

    Status: REVIEWED

    Conserved Domains (3) summary
    pfam05224
    Location:301451
    NDT80_PhoG; NDT80 / PhoG like DNA-binding family
    pfam13888
    Location:800933
    MRF_C2; Myelin gene regulatory factor C-terminal domain 2
    cl16452
    Location:498606
    Peptidase_S74_CIMCD; Peptidase S74 family, C-terminal intramolecular chaperone domain of Escherichia coli phage K1F endosialidase and related proteins
  5. NM_001381080.1NP_001367259.1  Myelin regulatory factor homolog 2, N-terminal [Caenorhabditis elegans]

    Status: REVIEWED

    Conserved Domains (3) summary
    pfam05224
    Location:298448
    NDT80_PhoG; NDT80 / PhoG like DNA-binding family
    pfam13888
    Location:797930
    MRF_C2; Myelin gene regulatory factor C-terminal domain 2
    cl16452
    Location:495603
    Peptidase_S74_CIMCD; Peptidase S74 family, C-terminal intramolecular chaperone domain of Escherichia coli phage K1F endosialidase and related proteins